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Moumoujus

THYMUS QUINQUECOSTATUS EXTRACT.

Valuable CAS 91770-86-4 / SKIN CONDITIONING

Thymus quinquecostatus extract is a botanical ingredient rich in beneficial compounds, demonstrating a spectrum of skin benefits including potent antioxidant, antimicrobial, and anti-inflammatory properties. It is recognized for its ability to target acne-causing bacteria, soothe irritation, and protect skin from oxidative stress while regulating sebum.

Summary

Antioxidant Antimicrobial Anti-inflammatory Sebum Regulation Skin Protection Anti-aging Skin Whitening Soothing Anti-acne

Science

Mechanism of Action

This extract operates through multiple pathways to improve skin health. Its antioxidant capabilities stem from its capacity to neutralize free radicals and mitigate oxidative stress, thereby helping to combat signs of skin aging and reduce reactive oxygen species. Antimicrobial action, particularly against acne-causing bacteria like Propionibacterium acnes, is attributed to components such as thymol and carvacrol, which disrupt bacterial cell membranes, increasing permeability and causing cell lysis. Furthermore, its anti-inflammatory effects are linked to the inhibition of Th1/2 cytokines and IgE, with caffeic acid and rosmarinic acid identified as key modulators. It also contributes to regulating sebum hypersecretion and provides anti-irritant activity, potentially offering skin protection and whitening benefits.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An *in vitro* study demonstrated anti-acne effects of *Thymus quinquecostatus* essential oil against *Propionibacterium acnes* and *Propionibacterium granulosum*.
  2. 02 Further *in vitro* research using water extracts showed cytoprotective and anti-apoptotic properties in liver cells, indicating strong antioxidant activity and enhanced cell viability.
  3. 03 Extracts induced cellular antioxidant activity in Caco-2 cells with no induction of cell death up to 50 μg/mL.
  4. 04 An *in vivo* mouse study with a 50% EtOH extract significantly reduced serum levels of inflammatory markers (TNF-α, IL-4, IL-5, IL-6, and IgE) in allergic rhinitis models, suggesting potent anti-inflammatory potential.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Volatile components, particularly in essential oils derived from thyme, are sensitive to heat. It is recommended to dry plant material at temperatures not exceeding 40°C to minimize the loss of these beneficial volatile compounds.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While *Thymus quinquecostatus* extract has not shown acute toxicity, genotoxicity, or teratogenic effects on spermatozoa in studies, it's important to note that high internal doses can potentially lead to toxicity in bone marrow cells, liver, and kidney, and may cause hypoglycemia or abnormal hematopoietic systems. For topical applications, related thyme extracts (*Thymus vulgaris*) have been associated with irritation or allergic reactions in sensitive individuals, manifesting as redness, itching, or dryness if used excessively. Patch testing is recommended for individuals with known sensitivities.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

With its comprehensive antioxidant, antimicrobial, and anti-inflammatory actions, *Thymus quinquecostatus* extract presents a valuable multi-functional ingredient for targeted skin concerns, particularly for oily, normal, and sensitive skin types.

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