Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

THYMOL TRIMETHOXYCINNAMATE.

Valuable / ANTIOXIDANT, SKIN PROTECTING

Thymol Trimethoxycinnamate is an innovative ingredient recognized for its dual action in skincare: effectively alleviating skin discomfort such as itching and irritation, while also demonstrating significant anti-melanogenic properties. It works to calm the skin and reduce the appearance of hyperpigmentation.

Summary

antioxidant skin protecting anti-itch anti-irritation anti-melanogenic

Science

Mechanism of Action

This compound alleviates skin itching and irritation by inhibiting voltage-gated sodium channel Nav1.7, which plays a role in nerve signal transmission. Furthermore, it actively addresses hyperpigmentation by promoting adiponectin synthesis, which in turn hinders melanin biosynthesis. It also directly binds to PPARγ, acting as a PPARγ partial agonist involved in pigmentation regulation. Beyond these targeted actions, Thymol Trimethoxycinnamate exhibits antioxidant properties by neutralizing reactive oxygen species and functions as a protective agent for the skin barrier.

Research

Clinical Evidence

High confidence
Effective range 0.001–20%
Optimal

N/A

Key findings

  1. 01 Alleviates skin itching or irritation.
  2. 02 Exhibits anti-melanogenic efficacy in normal human melanocytes and 3D human epidermal equivalents.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.001%
Red flag below
0.001%

While Thymol Trimethoxycinnamate is effective at concentrations as low as 0.001% for itch and irritation alleviation, formulations containing less than this minimum effective concentration may not deliver the full intended benefits. Optimal performance should be observed within the specified range, up to 20% where formulation stability is maintained.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The ingredient demonstrates good stability but is susceptible to hydrolysis under strongly acidic or alkaline conditions and is prone to oxidation. Formulation stability is also compromised at concentrations exceeding 20%.

Conflicts

  • strong acid
  • strong alkali
  • strong oxidants

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
20%
Sensitization risk Low

Thymol Trimethoxycinnamate shows low cytotoxicity in studies, and compositions containing it are reported to have excellent skin itch and irritation alleviation effects without side effects. However, the raw solid form may cause irritation to the skin, eyes, and respiratory system. For cosmetic use, it should be tested for harmful substances or microorganisms according to local regulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Thymol Trimethoxycinnamate is a valuable ingredient for addressing both skin discomfort and hyperpigmentation, offering calming, brightening, and protective benefits across all skin types when formulated correctly within its effective concentration range.

Related

Similar Ingredients

Finding similar ingredients…

References

Sources