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Moumoujus

THUJA PLICATA STEM EXTRACT.

Insufficient Data CAS 94334-32-4 / PERFUMING

Thuja Plicata Stem Extract is derived from the Western Red Cedar, known for its traditional uses. In skincare, it offers potential anti-inflammatory and tissue remodeling benefits, contributing to skin balance and regeneration.

Summary

Anti-inflammatory Antioxidant Antiseptic Skin Soothing Skin Regeneration Tissue Remodeling Support Fragrance Astringent Hair Conditioning

Science

Mechanism of Action

This extract is believed to exhibit anti-inflammatory effects by modulating the expression of key cellular adhesion molecules and chemokines such as VCAM-1, ICAM-1, IP-10, I-TAC, MIG, and M-CSF. It also demonstrates antiproliferative activity and influences tissue remodeling pathways through the inhibition of collagen-I, collagen-III, PAI-1, TIMP-1, and TIMP-2. Broader Thuja extracts are recognized for antioxidant, anti-inflammatory, and antiseptic properties, which collectively help protect the skin from oxidative stress, reduce inflammation, soothe irritation, and promote overall skin regeneration.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An in vitro study demonstrated that 0.011% Thuja plicata essential oil significantly inhibited the expression of various inflammatory biomarkers (VCAM-1, ICAM-1, IP-10, I-TAC, MIG, M-CSF) and key tissue remodeling proteins (collagen-I, collagen-III, PAI-1, TIMP-1, TIMP-2) in a pre-inflamed human dermal fibroblast culture model. This suggests potential anti-inflammatory and tissue remodeling capabilities, though these findings are specifically linked to the essential oil, not directly the stem extract.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Optimal pH range for stability is not specifically documented. As a general plant extract, it may contain both oil-soluble components (like those found in essential oils from Thuja plicata leaves) and water-soluble components (such as polysaccharides).

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

No specific safety assessments from CIR, SCCS, or FDA have been found for THUJA PLICATA STEM EXTRACT. Thuja plicata essential oil contains thujone, a compound considered toxic in large amounts, which is a consideration for extracts. General plant extracts have the potential to cause acute toxicity, skin/eye irritation, or sensitization with topical application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While promising in vitro data suggests anti-inflammatory and tissue remodeling potential from Thuja plicata essential oil, comprehensive clinical efficacy and specific safety assessments for THUJA PLICATA STEM EXTRACT are currently insufficient for a definitive rating.

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