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Moumoujus

THUJA PLICATA LEAF OIL.

Questionable CAS 94334-32-4 / PERFUMING

Thuja Plicata Leaf Oil, derived from the Western Red Cedar, is recognized for its potent anti-inflammatory and antimicrobial properties. It actively targets concerns such as inflammation, imbalanced sebum, and bacterial proliferation, making it relevant for precision skincare formulations, particularly for oily and acne-prone complexions.

Summary

Anti-inflammatory Antimicrobial Antibacterial Antifungal Astringent Antioxidant Sebum Balancing Purifying Cleansing Skin Conditioning Collagen Support Reduces Puffiness Antiproliferative

Science

Mechanism of Action

This oil functions by inhibiting specific proteins and genes critical to inflammatory pathways and immune responses, such as VCAM-1 and ICAM-1. It demonstrates antiproliferative activity in human dermal fibroblasts and exhibits broad-spectrum antibacterial and antifungal qualities. Rich in antioxidants and flavonoids, it defends against free radicals, aids in sebum regulation, and supports overall skin clarity and health.

Research

Clinical Evidence

Medium confidence
Effective range 0.011–2%
Optimal

0.5%

Key findings

  1. 01 Significantly inhibited numerous proteins and genes involved in inflammation and tissue remodeling, alongside demonstrating antiproliferative activity in human dermal fibroblast cell cultures.
  2. 02 Achieved complete eradication of various Gram-positive and Gram-negative human bacteria within one hour in saline solutions, highlighting robust antimicrobial effects.
  3. 03 Recommended for integration into skincare products, specifically to balance and refresh oily and acne-prone skin types.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.011%
Red flag below
0.005%

Thuja Plicata Leaf Oil exhibits distinct anti-inflammatory effects at 0.011% and antimicrobial activity at 0.1%. Formulations containing this ingredient below these scientifically evidenced thresholds for specific claims may indicate an insufficient concentration for functional impact, potentially qualifying as 'dusting'.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The essential oil may thicken due to a high concentration of Methyl Thujate, which can be remedied by gentle warming. Terpenes within the oil are prone to polymerization upon oxidation, potentially leading to solubility challenges in complex formulations.

Conflicts

  • Undiluted application
  • Use during pregnancy
  • Use with babies, children, and the elderly
  • Direct contact with eyes and mucous membranes
  • Internal consumption

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
2%
Pregnancy
Caution
Sensitization risk Moderate

EWG VERIFIED considers this ingredient restricted, requiring specific substantiation or usage restrictions due to potential concerns. It may induce skin irritation in some individuals; therefore, a prior skin patch test is advised. Given its abortifacient properties, it is contraindicated during pregnancy. Contains potentially neurotoxic components, thujone and camphor, and should be used cautiously and sparingly, particularly around vulnerable populations. Higher concentrations have shown toxicity in certain in vitro models.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While Thuja Plicata Leaf Oil offers compelling anti-inflammatory and antimicrobial benefits at precise concentrations, its significant safety concerns, including potential neurotoxicity and abortifacient properties, necessitate extreme caution and restricted use in precision skincare.

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