Science
Mechanism of Action
This extract exerts its dermatological effects primarily through potent anti-inflammatory action, specifically by inhibiting the release of pro-inflammatory cytokines such as interleukin-6, tumor necrosis factor-α, and monocyte chemotactic protein-1. This mechanism contributes to the reduction of erythema, melanin production, and skin thickening. It further aids in normalizing skin structure by decreasing epidermal hyperplasia and keratinization observed in inflamed conditions. Additionally, it possesses intrinsic antioxidant, antibacterial, and anti-allergic properties, alongside an ability to inhibit melanin synthesis, contributing to a clearer, more balanced complexion.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Topical application of ≥25 µg/day significantly prevented skin thickening in a dinitrofluorobenzene-induced mouse model of contact dermatitis.
- 02 Topical application of ≥75 µg/day produced significant improvements across various skin lesions, including roughness, excoriation, and scabs, in a dinitrofluorobenzene-induced mouse model of contact dermatitis.
- 03 Topical application of ≥250 µg/day significantly reduced epidermal hyperplasia in a dinitrofluorobenzene-induced mouse model of contact dermatitis.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Official review by CIR, SCCS, or FDA for Thuja Orientalis Seed Extract is not available in public databases. While the leaf extract has no reported GHS classification penalties, specific safety data for the seed extract is needed for a definitive assessment.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Thuja Orientalis Seed Extract shows strong preclinical evidence for anti-inflammatory, antioxidant, and skin-conditioning benefits, making it a valuable addition for soothing and protecting various skin types.
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References
Sources