Science
Mechanism of Action
The ornithine component of this compound is believed to increase the volume of dermal fatty tissue through the activation of the transcription factor HIF-1α, thereby producing a localized lipofilling effect. As an essential amino acid, ornithine supports critical metabolic pathways including protein synthesis, contributing to maintaining skin elasticity and promoting cellular regeneration. Furthermore, studies indicate it can enhance epidermal barrier function by increasing the presence of collagen-constituting amino acids (L-proline and glycine) and polyamines within the skin.
Research
Clinical Evidence
Medium confidence2%
Transparency
Dusting Analysis
No data suggests this ingredient is commonly used at ineffective 'dusting' percentages or to mislead consumers.
The Formula
Formulation
Stability
L-Ornithine, a key component, exhibits good stability at physiological pH (approximately 7.4) and standard body temperatures (37°C). However, it is susceptible to degradation under extreme pH conditions or prolonged thermal exposure. Additionally, its amino groups can be altered by exposure to oxidizing agents.
Conflicts
- oxidizing agents
- extreme pH conditions
Safety
Safety Profile
While THREONINAMIDO ORNITHINE specifically has not been reviewed by the CIR, L-Ornithine is generally recognized as a safe cosmetic ingredient by European Union regulatory authorities. In vitro genotoxicity assays and a 90-day rat oral toxicity study on L-ornithine monohydrochloride showed no evidence of genotoxicity or adverse systemic effects at dietary concentrations up to 5.0%. Nevertheless, due to individual sensitivities, a skin sensitivity patch test is recommended for products containing ornithine, particularly for individuals with sensitive skin, to mitigate potential allergic reactions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Threoninamido Ornithine is a valuable ingredient for advanced anti-aging formulations, specifically targeting wrinkle reduction and skin plumping through its unique lipofilling-like mechanism and support for skin regeneration.
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