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Moumoujus

THIODIPROPIONIC ACID.

Valuable CAS 111-17-1 / SKIN CONDITIONING

Thiodipropionic Acid functions as a multi-tasking ingredient, primarily serving as an antioxidant to preserve cosmetic formulations while also offering skin conditioning benefits. It works by inhibiting oxidation reactions, which helps maintain product integrity, and by aiding the skin in moisture retention, promoting a soft and smooth appearance.

Summary

Antioxidant Skin Conditioning Agent Preservative

Science

Mechanism of Action

This ingredient acts as a robust antioxidant, preventing or significantly slowing the degradation of cosmetic and personal care products by neutralizing oxidation reactions triggered by exposure to atmospheric oxygen. On the skin, it provides conditioning benefits, aiding in moisture retention to leave the skin feeling soft and smooth.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical evaluations predominantly focus on safety. Formulations containing the derivative Dilauryl Thiodipropionate at concentrations up to 4% demonstrated irritation in some subjects, though other formulations did not. However, Thiodipropionic Acid itself was not identified as a sensitizer or phototoxicant. Overall clinical testing showed no sensitization or photosensitization when formulated to be non-irritating.

Transparency

Dusting Analysis

Not commonly dusted

The provided research data does not contain information regarding ingredient dusting practices or thresholds for Thiodipropionic Acid.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Thiodipropionic Acid exhibits good stability, maintaining its integrity under recommended storage conditions and at ambient room temperature within closed containers, assuming normal handling.

Conflicts

  • Alcohols (carboxylic groups may react preferentially)
  • Amines (carboxylic groups may react preferentially)

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Thiodipropionic Acid and its dialkyl esters are safe for use in cosmetic products when properly formulated to be non-irritating. For its derivative, Dilauryl Thiodipropionate, a maximum dermal tested concentration of 0.05% was reported safe. Thiodipropionic Acid has been deemed non-genotoxic and not a developmental toxicant, with dermal studies consistently indicating a low risk of sensitization or phototoxicity. The U.S. FDA also lists Thiodipropionic Acid as Generally Recognized As Safe (GRAS) for use as a chemical preservative and antioxidant in food and food packaging materials. Information regarding its SCCS status is not available.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Thiodipropionic Acid is a valuable ingredient, contributing to product stability as an antioxidant and offering mild skin conditioning, all with a well-established low safety risk when properly formulated.

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