Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

THIOCTOYL TRIPEPTIDE-1.

Valuable / ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

THIOCTOYL TRIPEPTIDE-1 is a sophisticated derivative of Tripeptide-1 (GHK) integrated with thioctic acid, engineered to deliver robust antioxidant protection and support skin's structural integrity. It functions to promote collagen synthesis, scavenge harmful reactive species, and protect against environmental damage, ultimately contributing to a more youthful and resilient complexion.

Summary

Antioxidant Skin protecting Hair conditioning Collagen boosting Anti-aging Extracellular matrix support DNA protection

Science

Mechanism of Action

This ingredient operates as a derivative of Tripeptide-1 (Glycine-Histidine-Lysine, or GHK) linked with thioctic acid. The GHK component acts as a fragment of type I collagen, signaling the skin to enhance its natural collagen production, which can visibly reduce wrinkles. It also functions as a carrier peptide, facilitating the delivery and stabilization of copper within the skin, forming Copper-Tripeptide-1 (GHK-Cu). Beyond structural support, THIOCTOYL TRIPEPTIDE-1 scavenges Reactive Carbonyl Species (RCS), mitigating visible signs of premature aging induced by pollution and photo-aging. It stimulates the synthesis of extracellular matrix components, including collagen, hyaluronic acid, and other glycosaminoglycans (GAGs), while also protecting and stabilizing existing collagen fibers through an anti-collagenase effect. Furthermore, it offers protection against UVA-induced DNA damage in the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

This peptide derivative maintains optimal stability within a pH range of 3.5 to 6.5. Its parent peptide, Tripeptide-1, is known for rapid enzymatic degradation in biological systems. For aqueous solutions of related peptides, storage for longer than one day is not recommended. It requires storage in a dry, cool place, shielded from both light and heat.

Synergies

  • Copper (for GHK-Cu formation)

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.001%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Tripeptide-1 and its fatty acyl derivatives, including THIOCTOYL TRIPEPTIDE-1, are safe for use in cosmetic applications. Typical use concentrations are generally below 0.001% (10 ppm).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

As a multi-functional peptide derivative, THIOCTOYL TRIPEPTIDE-1 offers significant antioxidant and collagen-stimulating benefits, making it a valuable addition for anti-aging and protective skincare formulations.

Related

Similar Ingredients

Finding similar ingredients…