Science
Mechanism of Action
Teupolioside functions by directly neutralizing reactive oxygen species (ROS) and reactive nitrogen species (RNS), in addition to enhancing the skin's intrinsic antioxidant defenses. Its anti-inflammatory action is evidenced by reductions in pro-inflammatory cytokines, myeloperoxidase activity, and malondialdehyde levels, while also mitigating the upregulation of adhesion molecules like ICAM-1 and P-selectin to calm skin responses. It also possesses chelating properties for bivalent ions.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Pure Teupolioside demonstrated significant dose-dependent free radical scavenging activity against DPPH• and ABTS•+ in vitro, with an EC50 of 9.18 µg/mL.
Transparency
Dusting Analysis
Information regarding 'dusting' practices for Teupolioside in topical formulations is not available within the provided research data.
The Formula
Formulation
Stability
While a specific optimal pH range for Teupolioside stability is not documented, analogous phenylpropanoid glycosides, such as Verbascoside, exhibit enhanced stability in acidic conditions and are prone to accelerated degradation via glycosidic bond hydrolysis in neutral to alkaline environments.
Safety
Safety Profile
Teupolioside has received Novel Food certification for nutraceutical applications, indicating safety for ingestion. However, specific topical skincare safety assessments by regulatory bodies such as CIR, SCCS, or FDA have not been identified.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Teupolioside is a valuable ingredient due to its potent antioxidant and anti-inflammatory actions, broad skin compatibility, and low risk of irritation or comedogenicity, making it highly suitable for protective and soothing skincare formulations.
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References
Sources