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TETRASODIUM TETRACARBOXYMETHYL NARINGENINCHALCONE.

Valuable / SKIN CONDITIONING

Tetrasodium Tetracarboxymethyl Naringeninchalcone is a specialized polyphenol derivative engineered to precisely target and alleviate skin redness. It is particularly effective for sensitive skin conditions like rosacea, working to calm irritation and improve overall skin comfort.

Summary

Anti-inflammatory Anti-allergy Anti-redness Skin conditioning

Science

Mechanism of Action

This ingredient functions by directly influencing key physiological pathways associated with skin redness. It notably reduces capillary blood flow, thereby diminishing the visible signs of redness typical of conditions such as rosacea. Furthermore, it inhibits the release of specific pro-inflammatory cytokines, specifically LL-37 induced ones in human keratinocytes, which are implicated in inflammatory responses. As an anti-stress agent, it actively protects and provides comfort to stressed skin.

Research

Clinical Evidence

Medium confidence
Effective range 0.05–0.1%
Optimal

0.1%

Key findings

  1. 01 A manufacturer-sponsored clinical study involving 11 participants demonstrated that applying 0.1% of the ingredient twice daily for 56 days visibly reduced skin redness and improved the signs of rosacea.
  2. 02 A clinical study on volunteers with mild rosacea confirmed a measurable reduction in capillary blood flow and a visible diminution of rosacea redness after 56 days of treatment.
  3. 03 Recommended use levels for anti-redness, anti-inflammatory, and anti-stress effects, particularly for rosacea skin, range between 0.05% and 0.1%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH ≥5
0 7 14

Stability

This molecule exhibits greatly improved pH stability compared to the natural naringenin chalcone. Its water-solubility is strongly pH dependent, decreasing below pH 5.0. It is thermoresistant up to 60 °C for a short time and is compatible with homogenization processes. For optimal stability, products containing this ingredient should be shielded from light where possible.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by CIR, SCCS, or FDA were found for Tetrasodium Tetracarboxymethyl Naringeninchalcone. ULProspector indicates that no regulatory information is available at this time.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

A valuable ingredient for precision skincare, effectively targeting skin redness and inflammation, making it highly beneficial for sensitive and rosacea-prone skin.

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