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TETRASODIUM IMINODISUCCINATE.

Valuable CAS 144538-83-0 / CHELATING

Tetrasodium Iminodisuccinate is a multifaceted ingredient primarily utilized as a chelating agent. It significantly enhances product stability and efficacy by neutralizing interfering metal ions, while also contributing to improved textural qualities and offering soothing benefits for sensitive skin.

Summary

chelating agent stabilizer water softener skin soothing

Science

Mechanism of Action

This ingredient functions by chelating, effectively binding to various metal ions such as calcium, magnesium, iron, and copper. This action prevents these ions from destabilizing cosmetic formulations, thereby safeguarding active ingredient integrity, reducing oxidative degradation, and minimizing discoloration or rancidity in products containing unsaturated fats. Additionally, it acts as a water softener, which contributes to smoother product textures and better spreadability. It also provides skin-soothing properties that can help mitigate irritations, reducing redness and inflammation.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The provided research data does not contain information regarding dusting characteristics or specific concentration thresholds for undesirable effects.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 14
0 7 14

Stability

Tetrasodium Iminodisuccinate exhibits robust stability across a broad pH spectrum. It remains stable for several hours at 100°C in weakly acidic solutions (pH > 4-7) and for weeks at 50°C in strongly alkaline environments (pH > 4, up to 14). Below 50°C, its stability is not significantly affected by pH, maintaining at least 90% stability for over 24 weeks. It demonstrates strong compatibility with high pH and strong alkalis.

Conflicts

  • strong oxidizing agents
  • acids (for long-term storage)

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Tetrasodium Iminodisuccinate is safe as used in current cosmetic practices and concentrations. This assessment is supported by data indicating low systemic toxicity, minimal dermal irritation and sensitization potential, and no expected ocular or respiratory irritation. Regulatory agencies like the EPA and ECHA also consider it to pose minimal risk to human health and ecological systems.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Tetrasodium Iminodisuccinate is a valuable ingredient for optimizing cosmetic formulations, ensuring product stability and enhancing texture, with added benefits for sensitive skin.

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