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Moumoujus

TETRASODIUM GLUTAMATE DIACETATE.

Valuable CAS 51981-21-6 / CHELATING

Tetrasodium Glutamate Diacetate is a potent, biodegradable chelating agent vital for optimizing the stability and performance of skincare formulations. By sequestering metallic ions, it effectively prevents product degradation, preserves ingredient integrity, and bolsters the efficacy of preservative systems, contributing to a more stable and effective product lifespan.

Summary

Chelating Preservative Booster Stabilizer pH Stabilizer Active Penetration Enhancer Antiseptic Synergist

Science

Mechanism of Action

While primarily active within the product formulation, Tetrasodium Glutamate Diacetate's chelating action indirectly benefits the skin by ensuring the stability and efficacy of other active ingredients. It achieves this by binding and inactivating metallic ions, such as iron, copper, calcium, and magnesium, which typically accelerate oxidation and degradation, thus preventing product discoloration and breakdown. Furthermore, it enhances the performance of preservatives, stabilizes formulation pH, reduces water hardness, and may facilitate improved skin penetration of co-formulated active ingredients. Its interaction with bacterial cell walls also suggests a synergistic antiseptic effect, supporting overall product hygiene.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Tetrasodium Glutamate Diacetate serves as a critical functional ingredient for formulation stability rather than a direct skin active. Its role in chelating metallic ions and boosting preservative efficacy is crucial even at low concentrations, making the concept of 'dusting' for marketing purposes less applicable to its primary function.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This ingredient demonstrates robust stability and effectiveness across a broad pH spectrum, from highly acidic to strongly alkaline conditions. A 1% solution typically presents a pH between 10.0-12.0. It also maintains its integrity under elevated temperatures.

Synergies

  • Preservatives (boosts efficacy)
  • Bactericides (enhances efficacy)
  • Active ingredients (potential improved penetration)

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

The Expert Panel for Cosmetic Ingredient Safety (CIR) concluded in 2021 that Tetrasodium Glutamate Diacetate is safe for use in cosmetics at current concentrations and practices, with a highest reported use concentration of 1% in deodorants. A human repeat insult patch test (HRIPT) involving 104 subjects demonstrated no significant irritancy or sensitization at 0.2315%. While there was consideration for potential nitrilotriacetic acid (NTA) contamination, multiple in vitro and in vivo genotoxicity studies at typical cosmetic concentrations found no adverse genetic activity. It is also approved under EU Cosmetics Regulation (EC) No. 1223/2009 and classified as 'safe' by the FDA for certain applications.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Tetrasodium Glutamate Diacetate is a valuable ingredient for product stability, ensuring the integrity and extended efficacy of complex skincare formulations by neutralizing metallic ion contamination.

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