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Moumoujus

TETRAPEPTIDE-77.

Valuable / SKIN CONDITIONING - EMOLLIENT

TETRAPEPTIDE-77 is a sophisticated peptide engineered to modulate inflammatory pathways and enhance skin's structural integrity. It actively reduces the visible signs of aging by stimulating critical collagen and laminin production, leading to improved skin texture and a reduction in fine lines and wrinkles.

Summary

Skin conditioning Anti-aging Anti-inflammatory Collagen stimulating Firming Moisture restoring Anti-wrinkle

Science

Mechanism of Action

This peptide operates by significantly decreasing the production of interleukin-6 (IL-6), a primary inflammatory signaling molecule, thereby slowing the degradation of vital skin components like collagen. Simultaneously, it actively promotes the natural synthesis of collagen (specifically type VII) and laminin IV and V, contributing to enhanced dermal support, cellular renewal, and overall skin calming.

Research

Clinical Evidence

High confidence
Effective range 2–5%
Optimal

N/A

Key findings

  1. 01 Clinical evaluations at concentrations of 2-5% have demonstrated TETRAPEPTIDE-77's capacity to reduce IL-6 secretion and mitigate inflammation following UVB exposure. Further studies reveal its ability to stimulate the production of critical structural proteins, including laminin IV and V, and collagen VII. These actions collectively lead to restored skin moisture, a reduction in surface roughness, and a visible decrease in the appearance of fine lines and wrinkles.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The stability of peptide formulations, including TETRAPEPTIDE-77, is significantly influenced by the chosen excipients. Incompatibility with other ingredients can lead to aggregation, precipitation, or degradation of the peptide, potentially reducing its efficacy and raising safety concerns.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Tetrapeptide-7 (which is the INCI name for Palmitoyl Tetrapeptide-7, the peptide this data describes) is safe for use in cosmetics under current practices and concentrations for topical applications. While generally considered safe with a low risk of irritation or sensitization and deemed non-toxic, specific maximum use concentration data for Palmitoyl Tetrapeptide-7 was not provided in the original CIR assessment.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

TETRAPEPTIDE-77 is a valuable anti-aging and anti-inflammatory ingredient, offering comprehensive benefits for skin regeneration, texture refinement, and irritation minimization with a favorable safety profile.

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