TETRAPEPTIDE-72.

Palmitoyl Tetrapeptide-72 Amide, also recognized by the trade name Skinarch™, operates by significantly boosting the expression and production of Mohawk, a critical homeodomain protein abundant in young skin. This protein is essential for the regeneration of extracellular matrix (ECM) components and connective tissue. By elevating Mohawk levels, the peptide promotes the synthesis of various collagen types, enhances gene expression for ECM components, and downregulates enzymes that degrade structural proteins. This holistic action not only increases collagen production but also improves its density, organization, and fibril thickness, thereby strengthening the skin's supportive network.