Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

TETRAPEPTIDE-59.

Valuable / SKIN CONDITIONING

TETRAPEPTIDE-59, also known as Acetyl Tetrapeptide-5, is a synthetic tetrapeptide specifically designed to target and visibly reduce under-eye concerns. It effectively diminishes puffiness, dark circles, and improves skin elasticity by addressing fluid retention and supporting the skin’s structural integrity.

Summary

Reduces puffiness around the eyes Anti-aging Skin-soothing Anti-oedema Reduces dark circles Improves microcirculation Aids detoxification Anti-glycation Stimulates collagen production Stimulates elastin production Improves skin elasticity Reduces fine lines Reduces wrinkles Anti-inflammatory Reduces irritation Reduces redness Hydrating Antioxidant

Science

Mechanism of Action

This synthetic tetrapeptide operates as a multi-functional anti-oedema agent by actively decreasing water retention and inhibiting vascular permeability, thereby preventing fluid accumulation around the eyes. It enhances local microcirculation and aids in toxin removal, which contributes to minimizing dark circles and overall skin dullness. Furthermore, TETRAPEPTIDE-59 exerts anti-glycation effects to protect collagen and stimulates both collagen and elastin production, strengthening the skin’s architecture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Its anti-inflammatory properties soothe the skin, while also promoting optimal hydration and offering antioxidant protection against free radical damage.

Research

Clinical Evidence

High confidence
Effective range 0.01–0.01%
Optimal

0.01%

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to determine common dusting practices or typical market concentrations in relation to clinically effective dosages.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

TETRAPEPTIDE-59 demonstrates stability across a broad pH range of 5-8. The product mixture typically maintains a pH between 2 and 6.

Safety

Safety Profile

CIR Status
Unknown
Sensitization risk Low

Acetyl Tetrapeptide-5 is regarded as safe and non-toxic for topical cosmetic use. It is well-tolerated by most skin types, including sensitive skin, and has undergone dermatological testing. Scientific studies suggest a low incidence of side effects, and its components are not classified as hazardous substances under Regulation (EC) No. 1272/2008. Specific regulatory review statuses from bodies like CIR, SCCS, or FDA, or defined maximum concentration guidelines, were not identified in the available research.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

TETRAPEPTIDE-59 is a highly valuable peptide for precision skincare, clinically demonstrated to significantly reduce under-eye bags and dark circles while improving skin elasticity and delivering comprehensive anti-aging and soothing benefits.

Related

Similar Ingredients

Finding similar ingredients…