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Moumoujus

TETRAPEPTIDE-58.

Valuable / SKIN CONDITIONING

TETRAPEPTIDE-58 is a synthetic peptide distinguished by its multi-functional properties, particularly its significant contributions to anti-aging, wrinkle reduction, and robust antioxidant defense. Functioning as a key active component within more complex peptide structures, it delivers targeted improvements in skin firmness and cellular protection.

Summary

antioxidant skin conditioning anti-aging collagen booster wrinkle reducer skin firming cytoprotective

Science

Mechanism of Action

TETRAPEPTIDE-58 exerts its effects through a sophisticated dual mechanism. It incorporates the Cys-Gly-His-Lys motif, frequently recognized as GHK-peptide or Tripeptide-1, which effectively stimulates collagen proliferation, visibly enhancing skin texture and minimizing the appearance of wrinkles. Additionally, the Glutathion-like γ-Glu-Cys motif provides potent antioxidant capabilities, safeguarding dermal cells from oxidative stress and contributing to a brighter, more even skin tone. This combined action promotes improved skin firmness, elasticity, and optimized hydration.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Manufacturer tests on related heptapeptides, such as Glutamoyl Dipeptide-55 Gamma Tetrapeptide-58 (Catchitide-1 and Phytoheptapeptide), demonstrated a notable increase of over 150% in anti-aging impact and wrinkle smoothing efficacy compared to existing tripeptides.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 10.5
0 7 14

Stability

TETRAPEPTIDE-58 exhibits good stability in aqueous solutions across a broad pH range of 3.0 to 10.5. For optimal peptide integrity and to mitigate potential deamidation and oxidation, a narrower pH range of 3.0-5.0 is recommended. For formulation, it should be integrated into an emulsion system after it has cooled to 40°C or lower. Raw peptide materials require refrigeration for long-term stability. Its water solubility is attributed to the presence of charged/polar amino acids in its sequence.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

TETRAPEPTIDE-58 itself has not undergone specific safety assessments by the CIR or SCCS. However, peptides generally demonstrate a high safety profile with low irritation potential. Amino acids, the foundational building blocks of peptides, are commonly recognized as safe (GRAS) by the FDA for direct food additives, supporting the overall favorable safety perception of this ingredient class.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

TETRAPEPTIDE-58 is a valuable peptide for advanced skincare, offering a dual mechanism for robust anti-aging, wrinkle reduction, and antioxidant protection, supported by its favorable safety profile and broad skin compatibility.

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