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Moumoujus

TETRAPEPTIDE-51.

Valuable / SKIN CONDITIONING

Tetrapeptide-51 is a cutting-edge biomimetic peptide engineered to bolster the skin's intrinsic defense against genetic damage. By emulating the action of FOXO3a, it actively preserves genomic integrity, supporting the healthy function of essential skin cells and visibly delaying the signs of aging.

Summary

Skin-identical ingredient Antioxidant Cell-communicating ingredient Anti-aging DNA protection Genomic integrity Cell vitality enhancer

Science

Mechanism of Action

This peptide operates by mimicking FOXO3a, a pivotal transcription factor responsible for regulating the cellular response to DNA damage. Through this biomimetic action, Tetrapeptide-51 stimulates the skin's natural repair mechanisms, preventing errors in DNA replication to maintain genomic integrity. This process ultimately slows the visible onset of skin aging and fosters optimal function across fibroblasts, keratinocytes, and melanocytes.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

2%

Key findings

  1. 01 At a 2% concentration, this peptide actively supports healthier function of fibroblasts, keratinocytes, and melanocytes, contributing to a reduction in the visible manifestations of aging.
  2. 02 In human epidermal cells, Tetrapeptide-51 demonstrated a 13.7% decrease in genetic damage induced by UV radiation within 6 hours. Furthermore, it significantly increased the viability of human dermal fibroblasts exposed to irradiation by 35.1% compared to untreated irradiated cells.

Transparency

Dusting Analysis

Not commonly dusted

Specific data regarding Tetrapeptide-51 being a 'dusted' ingredient or associated thresholds is not available in the provided research.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

For optimal preservation of its efficacy and freshness, Tetrapeptide-51 is recommended to be stored under refrigeration. It is formulated for incorporation into finished products or custom blends, and is particularly suitable for serum bases, rather than direct skin application.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Direct safety evaluations for Tetrapeptide-51, or its common variant Acetyl Hexapeptide-51 Amide, by regulatory bodies such as CIR, SCCS, or FDA, are not currently published. While general assessments exist for broader peptide categories, specific ingredient data is pending.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Tetrapeptide-51 is a valuable ingredient for advanced anti-aging formulations, uniquely targeting genomic integrity and providing significant cellular protection against environmental stressors.

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