Science
Mechanism of Action
Acetyl Tetrapeptide-5 diminishes under-eye puffiness by reducing water retention and swelling, enhancing lymphatic drainage, and decreasing vascular permeability. It minimizes dark circles through improved microcirculation and reduced pigmentation. The peptide fortifies skin structure, inhibiting the glycation process to prevent the formation of AGEs that degrade collagen and elastin, thereby improving skin elasticity. It also supports Superoxide Dismutase (SOD) activity, providing protection against oxidative stress, and influences Angiotensin-Converting Enzyme (ACE) to promote balanced microcirculation and vasodilation. Additionally, it helps maintain optimal epidermal moisture and exhibits anti-inflammatory properties, reducing skin sensitivity.
Research
Clinical Evidence
High confidence0.01%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient is stable within a broad pH range of 3.5 to 8.0. To maintain its integrity, avoid exposing it to temperatures exceeding 40°C during the formulation process. It should be incorporated as the final step in product manufacturing.
Safety
Safety Profile
Acetyl Tetrapeptide-5 is generally recognized as safe, non-toxic, and non-irritating for topical cosmetic application, even on sensitive skin, with a low incidence of side effects. While Safety Data Sheets for the raw, concentrated chemical may list hazard statements, these are not representative of its risk in diluted cosmetic formulations. Regulatory bodies affirm its safety and effectiveness, and SkinSAFE data supports its suitability across various sensitive categories, including eye and baby products, being free from common irritants.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tetrapeptide-5 is a valuable ingredient, demonstrating significant clinical efficacy in reducing under-eye puffiness and dark circles, complemented by broad anti-aging, moisturizing, and soothing benefits for all skin types.
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