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Moumoujus

TETRAPEPTIDE-40.

Valuable / SKIN CONDITIONING

Tetrapeptide-40 is a synthetic peptide engineered to normalize the skin's inflammatory response, significantly reducing redness and irritation. It also actively combats signs of aging by improving skin elasticity and diminishing the appearance of wrinkles, while enhancing overall skin hydration.

Summary

Anti-inflammatory Soothing Anti-aging Wrinkle Reduction Improves Elasticity Hydrating Skin Barrier Support Redness Reduction Reduces Post-Inflammatory Hyperpigmentation Photoprotection

Science

Mechanism of Action

This synthetic peptide, often known as Acetyl Tetrapeptide-40, primarily functions by decreasing the release of pro-inflammatory interleukins (IL-6 and IL-8), thereby mitigating conditions such as erythema and visible capillaries. It neutralizes inflammatory pathways, which helps to lessen post-inflammatory hyperpigmentation and protect against UV-induced damage. Furthermore, Tetrapeptide-40 inhibits Matrix Metalloproteinases (MMPs) that degrade collagen, thus maintaining skin firmness, and significantly reduces Substance P levels, a neurotransmitter associated with inflammation, itching, and swelling. The peptide also supports skin barrier integrity through keratinocyte differentiation and lipid synthesis, improves moisture balance, and promotes the production of collagen (types I and III) and elastin, with some evidence suggesting a 'Botox-like' effect on dynamic wrinkles.

Research

Clinical Evidence

High confidence
Effective range 0.01–0.1%
Optimal

0.05%

Key findings

  1. 01 Clinical investigations at concentrations between 0.01% and 0.1% demonstrate effectiveness in addressing dynamic wrinkles, loss of firmness, dehydration, and rough texture.
  2. 02 Studies reported reductions in wrinkle depth ranging from 10% to 30% over 4 to 12 weeks, alongside improvements in skin elasticity and hydration in placebo-controlled settings.
  3. 03 It has also been shown to decrease Substance P levels by up to 70%, effectively reducing irritation-induced redness, itching, and swelling, while exhibiting anti-inflammatory and soothing properties at 0.05%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

For optimal stability, Tetrapeptide-40 should be formulated within a pH range of 5.0 to 7.0, as extreme acidic or alkaline conditions can lead to its degradation. High heat during manufacturing processes can also denature the peptide. Utilizing encapsulation technologies, such as liposomes or nanospheres, can enhance its dermal penetration. Formulations with significant water content necessitate adequate preservation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Tetrapeptide-40 is generally recognized as safe for topical application in cosmetic products and is approved for use in the EU, US, and Asia. It is associated with a low concern for skin, eye, or lung irritation by the EWG. However, specific data regarding its topical use during pregnancy and breastfeeding is currently limited, making consultation with a healthcare professional advisable for these populations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Tetrapeptide-40 is a valuable peptide offering comprehensive benefits, particularly in inflammation reduction, anti-aging, and skin barrier support, suitable for a wide range of skin types.

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