Science
Mechanism of Action
This peptide operates by signaling dermal cells to augment the biosynthesis of key extracellular matrix components, primarily collagen. This targeted cellular stimulation works to bolster the structural integrity and firmness of the skin, thereby improving elasticity and diminishing the visibility of fine lines and wrinkles.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Often encountered as Palmitoyl Tetrapeptide-38 in formulations, this ingredient was included in the FDA's Voluntary Cosmetic Registration Program (VCRP) in 2012. Independent safety assessments from SkinSAFE classify it as 'Teen SAFE', 'Baby SAFE', 'Eyelid SAFE', 'Irritant Free', 'Fragrance Free', and 'Paraben Free', collectively indicating a favorable safety profile across diverse user populations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While Tetrapeptide-38 presents a promising mechanism for stimulating collagen and enhancing skin matrix integrity, and is supported by a generally favorable safety profile from SkinSAFE, the current lack of comprehensive clinical efficacy studies and 'insufficient data' status from CIR necessitate further research for a conclusive performance rating.
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References
Sources