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TETRAPEPTIDE-38.

Insufficient Data / SKIN CONDITIONING

Tetrapeptide-38 is a synthetic peptide engineered to stimulate the skin's endogenous production of collagen and other vital structural proteins. This action reinforces the dermal matrix, resulting in enhanced skin elasticity, a noticeable reduction in the appearance of wrinkles, and improved overall skin texture.

Collagen synthesis booster Extracellular matrix reinforcement Skin elasticity enhancer Wrinkle reduction Fine line minimization Skin texture improvement

Science

This peptide operates by signaling dermal cells to augment the biosynthesis of key extracellular matrix components, primarily collagen. This targeted cellular stimulation works to bolster the structural integrity and firmness of the skin, thereby improving elasticity and diminishing the visibility of fine lines and wrinkles.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

CIR Status
Insufficient data available from the Cosmetic Ingredient Review (CIR) Expert Panel.
Sensitization risk Low

Often encountered as Palmitoyl Tetrapeptide-38 in formulations, this ingredient was included in the FDA's Voluntary Cosmetic Registration Program (VCRP) in 2012. Independent safety assessments from SkinSAFE classify it as 'Teen SAFE', 'Baby SAFE', 'Eyelid SAFE', 'Irritant Free', 'Fragrance Free', and 'Paraben Free', collectively indicating a favorable safety profile across diverse user populations.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Insufficient Data

While Tetrapeptide-38 presents a promising mechanism for stimulating collagen and enhancing skin matrix integrity, and is supported by a generally favorable safety profile from SkinSAFE, the current lack of comprehensive clinical efficacy studies and 'insufficient data' status from CIR necessitate further research for a conclusive performance rating.


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