Science
Mechanism of Action
TETRAPEPTIDE-37 functions primarily by modulating the skin's inflammatory response through the reduction of interleukin-6 (IL-6), a prominent pro-inflammatory cytokine. Elevated concentrations of IL-6 accelerate the degradation of crucial structural proteins like collagen, thereby contributing to accelerated skin aging. By inhibiting IL-6, this peptide effectively minimizes inflammation, fostering an environment conducive to increased collagen synthesis, improved skin elasticity, and a reduction in the appearance of wrinkles and skin sagging. Additionally, it is believed to stimulate phagocytosis, enhancing the skin's innate defense mechanisms and facilitating the clearance of cellular debris. Evidence also suggests its role in promoting the regeneration of dermal collagen fibers and increasing skin's hyaluronic acid content, which collectively contribute to skin tightening and a more even complexion.
Research
Clinical Evidence
High confidence3%
Transparency
Dusting Analysis
The provided research data does not contain specific information regarding dusting practices for TETRAPEPTIDE-37. However, the demonstrated clinical efficacy at concentrations as low as 3% suggests that higher, potentially 'dusted' percentages are not necessary to achieve significant skin benefits.
The Formula
Formulation
Stability
For optimal stability within final cosmetic formulations, TETRAPEPTIDE-37 performs best within a pH range of 4.5 to 6.5. For raw material or concentrated stock solutions, rigorous storage is critical: maintain at -80°C for up to 6 months or -20°C for 1 month, ensuring the container is sealed and protected from moisture and light, to prevent inactivation from repeated freeze-thaw cycles. Prior to opening, stock solutions should be allowed to warm to room temperature to prevent condensation. Finished products containing the peptide should be stored in a refrigerator at 4-8°C, in a dry and dark environment, to preserve efficacy.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that TETRAPEPTIDE-37 (referred to as Palmitoyl Tetrapeptide-7 in their review) is safe for use in cosmetics under current practices and concentrations. Typical use concentrations in cosmetic formulations are generally quite low, often less than 10 ppm, though can extend up to 30 ppm for certain peptide ingredients. It is considered non-toxic and presents a low risk of irritation or sensitization, making it suitable for a wide range of cosmetic applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
TETRAPEPTIDE-37 is an essential and highly valuable anti-aging and skin-restoring peptide, demonstrating robust clinical efficacy in enhancing skin firmness, elasticity, and reducing wrinkle depth, underpinned by its powerful anti-inflammatory and collagen-boosting mechanisms, making it suitable for all skin types including sensitive.
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