Science
Mechanism of Action
Operating at a cellular level, Tetrapeptide-23, specifically as Azeloyl Tetrapeptide-23, actively combats oxidative damage and interrupts the glycation of dermal proteins. This action inhibits the formation of Advanced Glycation End products (AGEs) within the skin's structural matrix, thereby promoting cellular renewal. The ingredient also contributes to a noticeable improvement in skin elasticity, density, and brightness.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Clinical photo-imaging analysis revealed a 10% reduction in profilometric parameters, leading to wrinkles appearing less evident and deep.
- 02 In vitro testing confirmed that the product containing Azeloyl Tetrapeptide-23 reduced antioxidant activity by 60%, inhibited the formation of Advanced Glycation End products (AGEs) in human fibroblasts by up to 50%, and reduced free radical scavenging activity by 40%.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The Azeloyl Tetrapeptide-23 derivative incorporates a lipophilic carrier to enhance its antioxidant efficacy. For general peptide stability in aqueous solutions, a buffered pH range of 3-5 is often recommended to mitigate deamidation and oxidation processes.
Conflicts
- Substances releasing aldehydes (general for peptides)
Safety
Safety Profile
Tetrapeptide-23 has not undergone specific safety assessments by regulatory bodies such as CIR, SCCS, or FDA. The Cosmetic Ingredient Review (CIR) typically does not take action on ingredients without reported uses, indicating a current absence of extensive independent review.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tetrapeptide-23 offers multi-faceted anti-aging benefits through its proven antioxidant and anti-glycation actions, coupled with visible wrinkle reduction, making it a valuable addition to targeted skincare.
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References
Sources