Science
Mechanism of Action
Tetrapeptide-14 functions by specifically down-regulating interleukin-6 (IL-6), a pivotal pro-inflammatory signaling molecule. This targeted action prevents and reduces inflammation, consequently mitigating matrix metalloproteinase-1 (MMP-1) induced damage, which can lead to a brighter, more uniform skin appearance and a reduced likelihood of post-inflammatory pigmentation. Additionally, it actively stimulates the synthesis of essential collagen and elastin proteins, thereby strengthening the skin's architecture and curbing their degradation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In a 4-week study, a leave-on cosmetic treatment containing 5% of an active complex (Granactive AR-1423), which includes Tetrapeptide-14, effectively reduced rosacea-associated redness by 50%.
- 02 Formulations incorporating a peptide equivalent to 2.5% Tetrapeptide-30 Solution demonstrated significant improvements in overall skin appearance after 2 weeks, achieved more even skin tone after 4 weeks, and notably reduced skin lesions.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Tetrapeptide-14 is described as stable.
Conflicts
- Alpha hydroxy acids (AHAs) may reduce the efficacy of peptides.
Safety
Safety Profile
Extensive safety indications from SkinSAFE designate Tetrapeptide-14 as 'Teen SAFE', 'Baby SAFE', and 'Eyelid SAFE'. It is also free from common irritants and allergens, including fragrance, parabens, gluten, soy, and dyes, suggesting a very favorable safety profile for sensitive individuals.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tetrapeptide-14 is a valuable ingredient for advanced skincare, offering potent anti-inflammatory and skin-strengthening benefits, particularly suitable for sensitive, reactive, and aging skin types to promote an even and calm complexion.
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