Science
Mechanism of Action
This peptide actively stimulates hair and eyelash growth by directly activating SMAD2 and initiating the binding of SMAD3 with DNA. It simultaneously boosts keratinocyte proliferation, which leads to improvements in skin appearance, firmness, elasticity, and thickness. Furthermore, Tetrapeptide-12 exerts anti-inflammatory effects by mimicking natural signaling molecules to inhibit the NF-κB pathway, thereby reducing erythema and sensitivity, and reinforces the skin barrier through promoting tight junction protein synthesis.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Myristoyl Tetrapeptide-12 has been shown to improve the appearance of eyelashes and eyebrows, resulting in a fuller, more defined look with enhanced length and density upon regular application.
- 02 By increasing keratinocyte proliferation, Myristoyl Tetrapeptide-12 contributes to improvements in skin appearance, firmness, elasticity, and thickness.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For optimal stability, store Tetrapeptide-12 in a cool, dry place at 2-8°C, away from light. Long-term storage should be at -20°C to -15°C in an airtight container. Short-term storage (up to one week) is permissible at 4°C, while long-term storage (up to 6 months) requires temperatures between -20°C and -80°C. It is critical to avoid repeated freeze-thaw cycles and protect the ingredient from moisture. The powder form remains stable at -20°C for 3 years, and in solvent at -80°C for 1 year.
Safety
Safety Profile
Myristoyl Tetrapeptide-12 is recognized for its safety profile, being free from heavy metals and irritants, with no reported instances of skin or eye irritation. Peptides, in general, are highly regarded for their low irritation potential and overall safety in cosmetic applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tetrapeptide-12 is a valuable and multifaceted ingredient that offers comprehensive benefits, from enhancing lash and brow appearance to improving key indicators of skin health such as firmness, elasticity, and barrier function.
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