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Moumoujus

TETRAMETHYLCYCLOHEXANEPROPANOL.

Valuable CAS 4361-23-3 / PERFUMING

TETRAMETHYLCYCLOHEXANEPROPANOL, also identified as 4-t-butylcyclohexanol, is a sophisticated ingredient designed to precisely target and mitigate sensations of skin discomfort such as stinging, burning, and general irritation. It functions by actively enhancing the skin's tolerance threshold, making it particularly beneficial for sensitive and reactive skin types.

Summary

soothing masking perfuming

Science

Mechanism of Action

This ingredient operates at a cellular level by intercepting irritation signals before they activate neuro-receptors. Specifically, it modulates the TRPV1 (transient receptor potential vanilloid 1) receptors, which are critically involved in the sensation of pain and irritation. Through its inhibitory action on these receptors, TETRAMETHYLCYCLOHEXANEPROPANOL effectively reduces the skin's reactivity to environmental stressors and irritants, thereby minimizing feelings of discomfort, visible redness, and itching.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vivo studies demonstrate a significant immediate anti-stinging and anti-burning effect. Manufacturer data indicates it can reduce stinging by up to 78% and burning sensation by up to 80% within just 3 minutes of application.
  2. 02 A clinical trial on 33 subjects with hypersensitive skin revealed that a facial cream or balm containing this ingredient immediately reduced skin hypersensitivity (93.9% for cream, 81.8% for balm), redness (90.9% for cream, 87.9% for balm), tightness (93.9% for cream, 97.0% for balm), and overall discomfort (93.9% for cream, 87.9% for balm).
  3. 03 An 8-week clinical trial involving 48 patients showed a skincare cream containing this ingredient significantly decreased perioral dermatitis severity scores, improved subjective numerical rating scores, and enhanced quality of life.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Synergies

  • Licochalcone A

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
4%
Sensitization risk Low

No skin sensitization reactions were observed in a human maximization test at a 4% concentration. It was found not to be a skin irritant in rabbits and not sensitizing in a guinea pig maximization study. However, aggregated GHS information indicates it 'Causes serious eye irritation' (H319) in 86.5% of reports, necessitating careful handling.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

TETRAMETHYLCYCLOHEXANEPROPANOL is a valuable ingredient for precision skincare, demonstrating strong clinical efficacy in reducing skin hypersensitivity, stinging, and burning sensations by modulating sensory receptors, making it ideal for formulations targeting sensitive and reactive skin conditions.

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