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TETRAHYDROXYPROPYL ETHYLENEDIAMINE.

Valuable CAS 102-60-3 / CHELATING

Tetrahydroxypropyl Ethylenediamine (THPE) is a multifunctional ingredient recognized for its rapid skin tensioning effects and contributions to overall formulation stability. It works by influencing epidermal cell morphology while also acting as a chelating agent and pH regulator, making it a versatile component in advanced skincare formulations.

Summary

Skin tensioning agent Chelating agent Buffering agent Emulsion stabilizer

Science

Mechanism of Action

THPE primarily induces morphological alterations in superficial epidermal keratinocytes, leading to immediate cell contraction and a visible skin-tensioning effect. Beyond its direct skin benefits, it functions as a potent chelating agent, binding to detrimental metal ions like iron, calcium, and magnesium to prevent oxidative reactions and maintain product integrity. Additionally, THPE serves as a buffering agent to stabilize pH and as an emulsion stabilizer, enhancing formulation robustness.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

2.5%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

THPE is valued for its pH-regulating properties, making it effective in controlling pH-sensitive formulations and stabilizing active ingredients to extend product shelf life. Its stable chemical structure ensures efficacy across a wide range of temperatures. It forms clear solutions with various solvents, including water, ethanol, isopropanol, and propylene glycol. Gels formulated with THPE exhibit excellent alcohol compatibility and provide a pleasant, non-tacky skin feel. It also demonstrates a lower tendency to form nitroamines compared to other amine-containing bases.

Synergies

  • Enhances stability of pH-sensitive actives
  • Prevents degradation from metal ions

Conflicts

  • strong oxidizers
  • heat sources
  • direct sunlight
  • moisture

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel and the European Commission have concluded that THPE is safe for use in cosmetics at typical concentrations up to 0.5%. While clinical studies demonstrating anti-aging efficacy utilized a 2.5% concentration, regulatory bodies recommend a maximum concentration of 0.5% for general use. It is generally well-tolerated with low irritancy, and studies suggest minimal skin absorption. However, individuals with sensitive skin should perform a patch test due to rare reports of irritation or allergic reactions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Tetrahydroxypropyl Ethylenediamine is a valuable ingredient for its immediate skin-lifting effects, proven at 2.5% concentration, and its crucial role in formulation stability, though its practical use concentration requires careful consideration of regulatory recommendations (max 0.5%).

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