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Moumoujus

TETRAHYDROPALMATINE HCL.

Avoid CAS 6024-85-7 / ANTIOXIDANT, REDUCING

Tetrahydropalmatine HCL is an alkaloid derived from traditional medicinal plants, primarily recognized for its diverse pharmacological activities. While research suggests potential anti-inflammatory and neuroprotective properties, its potent nature necessitates extreme caution for skincare applications.

Summary

Anti-inflammatory Neuroprotective

Science

Mechanism of Action

Tetrahydropalmatine HCL exerts anti-inflammatory effects by inhibiting pro-inflammatory mediators such as IL-8 production and blocking MAPK phosphorylation in LPS-stimulated THP-1 cells. Furthermore, it demonstrates the ability to inhibit osteoclast formation in vitro. Its broader pharmacological profile includes antagonism of dopamine, alpha adrenergic, and serotonin receptors, as well as calcium channel blocking, though the precise topical mechanisms relevant to skin benefit are not fully elucidated.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Inhibition of osteoclast formation in vitro without cytotoxicity at concentrations less than 19.00 µg/ml.
  2. 02 Dose-dependent inhibition of LPS-induced IL-8 production and blockage of MAPK phosphorylation in human monocytic THP-1 cells, indicating anti-inflammatory effects.

Transparency

Dusting Analysis

Not commonly dusted

Tetrahydropalmatine HCL is a pharmacologically active compound with significant safety concerns and is not a commonly used or 'dusted' ingredient in cosmetic formulations. Its potent effects and warnings preclude its casual inclusion in skincare products.

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 5
0 7 14

Stability

Optimal stability is achieved in a mild acidic environment, typically between pH 3 and 5, which facilitates protonation. Degradation may occur under strongly acidic conditions or at elevated temperatures.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Moderate

Tetrahydropalmatine HCL carries significant safety warnings primarily from its recognized pharmacological applications. The Chinese National Medical Products Administration advises against its use in pregnant women and individuals with extrapyramidal disorders. Warnings also include risks of liver impairment, drowsiness, and extrapyramidal symptoms, particularly with overuse or when combined with other central nervous system depressants. Long-term use is not recommended due to potential cardiac and neurotoxic effects, advising caution in patients with heart diseases. PubChem also lists Tetrahydropalmatine as an 'Irritant'.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its potent pharmacological activity, significant safety warnings including potential irritancy and systemic toxicity, and a critical lack of specific topical safety and efficacy data, Tetrahydropalmatine HCL is not suitable for cosmetic formulations.

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