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Moumoujus

TETRADECYL AMINOBUTYROYLVALYLAMINOBUTYRIC UREA TRIFLUOROACETATE.

Avoid CAS 934368-60-2 / SKIN CONDITIONING

This peptide, also recognized as SYN®-HYCAN, is engineered to enhance skin's natural production of hyaluronic acid and collagen, leading to improved hydration and a firmer appearance. However, its trifluoroacetate component classifies it as a PFAS, raising significant health and environmental concerns.

Summary

Skin-identical ingredient Cell-communicating ingredient Humectant Skin-firming Skin-plumping Extracellular Matrix Support

Science

Mechanism of Action

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, a small peptide under 500 Da, actively stimulates skin fibroblasts to synthesize high molecular weight hyaluronic acid, approximately 2 MDa, thereby boosting hydration and promoting regeneration within the extracellular matrix. Concurrently, it supports collagen production for improved skin firmness and strength, while increasing the expression of proteoglycans like decorin and lumican, crucial for the formation and quality of new collagen fibrils, contributing to a visible remodeling effect.

Research

Clinical Evidence

High confidence
Effective range 2–3%
Optimal

N/A

Key findings

  1. 01 When included in a blend, this ingredient notably improves the skin's biomechanical properties and maintains surface hydration. Studies spanning 8 weeks on human skin demonstrated a visibly firmer appearance and smoother texture.
  2. 02 Research indicates enhanced skin volume and firmness, with over 87% of participants reporting smoother, more supple skin and nearly 70% confirming improved elasticity, supporting its role in non-invasive facial remodeling.
  3. 03 An open-label clinical study involving 33 women aged 45–65 showed improved facial contouring, skin firmness, hydration, and elasticity after 56 days, along with subjective improvements in skin texture and reduced sagging and wrinkles.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The trifluoroacetate component of this ingredient is classified as a Per- and Polyfluoroalkyl Substance (PFAS), known for its environmental persistence and potential for bioaccumulation. The Environmental Working Group (EWG) assigns a high safety concern rating of 10, highlighting moderate concerns for endocrine disruption and non-reproductive organ system toxicity. The FDA also lists this compound as a common PFAS found in cosmetics.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its demonstrated efficacy in enhancing skin hydration, firmness, and texture through hyaluronic acid and collagen stimulation, the classification of its trifluoroacetate component as a PFAS raises critical safety and environmental concerns, making it an ingredient to unequivocally avoid.

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