Science
Mechanism of Action
This ingredient functions as a potent anti-allergic and anti-inflammatory agent. Its sophisticated mechanism involves specifically reducing the release of LL-37 induced pro-inflammatory cytokines in keratinocytes and diminishing capillary blood flow. This dual action directly targets and alleviates rosacea-associated redness, while simultaneously protecting and comforting stressed skin by down-regulating various pro-inflammatory mediators.
Research
Clinical Evidence
Medium confidence0.1%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The modified molecular structure confers superior pH stability compared to natural naringenin chalcone. Its water-solubility is highly pH-dependent, decreasing below a pH of 5.0. The ingredient remains stable during homogenization and short-term exposure to temperatures up to 60 °C. For optimal preservation, finished formulations should be shielded from light.
Safety
Safety Profile
While no specific CIR, SCCS, or FDA regulatory status has been established, the ingredient's safety profile has been attested through standard cosmetic industry tests, including cell viability, human photo patch test, ocular irritation, and reverse mutation assay.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tetracarboxymethyl Naringeninchalcone is a valuable active for precision skincare, demonstrating clinically supported efficacy in reducing redness and inflammation, making it particularly beneficial for sensitive and rosacea-prone skin types.
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