Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

TETRACARBOXYMETHYL DIHYDROXYBENZOYL DIPEPTIDE-12.

Valuable / SKIN CONDITIONING

TETRACARBOXYMETHYL DIHYDROXYBENZOYL DIPEPTIDE-12 is a cutting-edge peptide engineered to activate critical cellular rejuvenation pathways. It is designed to enhance skin barrier function, improve hydration, and deliver comprehensive anti-aging benefits, resulting in visibly healthier and more resilient skin.

Summary

Skin conditioning Anti-aging Moisturizing Anti-inflammatory Antioxidant Brightening

Science

Mechanism of Action

This advanced peptide is theorized to function through mechanisms observed in closely related compounds, acting as a direct activator of Sirtuin1 (SIRT1). SIRT1, an NAD+-dependent deacetylase enzyme, plays a crucial role in regulating cellular metabolism, survival, and lifespan. By deacetylating target proteins such as FoxO1, it initiates protective cell autophagy, promoting cell rejuvenation, extending cellular lifespan, and slowing aging processes. Furthermore, this peptide is understood to significantly improve skin barrier function and water-retaining ability, acting as a natural moisturizing factor to enhance hydration. It also exhibits potent free radical scavenging activity, provides anti-inflammatory effects, and can reduce melanin content by stimulating autophagic flux and promoting melanosome degradation.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.05%
Optimal

N/A

Key findings

  1. 01 Research on a closely related peptide, Hexacarboxymethyl Dipeptide-12, at 0.05%, demonstrated superior efficacy compared to 2% low molecular weight hyaluronic acid in improving skin barrier function, enhancing water retention, and decreasing transdermal moisture loss. This peptide also exhibited significant free radical scavenging activity and anti-inflammatory effects, leading to a reduction in acne appearance by up to 65%.
  2. 02 Topical application of Pentasodium Tetracarboxymethyl Palmitoyl Dipeptide-12 (PTPD-12) effectively improved sensitive skin conditions through dual mechanisms of skin barrier strengthening and anti-inflammation. It also successfully reduced melanin levels in individuals experiencing hyperpigmentation.
  3. 03 A related peptide, Pentasodium Tetracarboxymethyl Hexanoyl Dipeptide-12 (PTHD-12), at a concentration of 0.01% in a final formulation, was found to attenuate UV-induced skin damage.

Transparency

Dusting Analysis

Not commonly dusted

As a complex active peptide, TETRACARBOXYMETHYL DIHYDROXYBENZOYL DIPEPTIDE-12 is designed for its specific biological effects at low, efficacious concentrations, making it unsuitable for use merely as a filler ingredient.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

TETRACARBOXYMETHYL DIHYDROXYBENZOYL DIPEPTIDE-12 has not undergone specific safety assessment by CIR, SCCS, or FDA. However, closely related peptides, such as Pentasodium Tetracarboxymethyl Palmitoyl Dipeptide-12, have been reported in clinical studies to be well-tolerated with no significant skin irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

TETRACARBOXYMETHYL DIHYDROXYBENZOYL DIPEPTIDE-12 offers a promising multi-functional approach to skin health, with strong evidence from closely related peptides supporting its role in cellular rejuvenation, barrier enhancement, and targeted skin concerns.

Related

Similar Ingredients

Finding similar ingredients…