Science
Mechanism of Action
This extract operates as a potent antioxidant, effectively neutralizing various free radicals including DPPH, superoxide anion, hydrogen peroxide, and hydroxyl radicals, alongside demonstrating ferrous chelation. Its anti-aging efficacy stems from protecting against oxidative stress by inhibiting the MAPK signaling pathway, thereby reducing detrimental expressions of c-Jun, c-Fos, MMP-1, MMP-3, MMP-9, and cyclooxygenase-2. Concurrently, it enhances hemeoxygenase-1 and helps restore type I procollagen expression in fibroblasts. Furthermore, it safeguards skin from photodamage via the MAPK/AP-1/MMP pathway inhibition. Its anti-inflammatory benefits are attributed to the inhibition of key enzymes such as phospholipase A2, lipoxygenase, and phosphodiesterase. Beyond this, it accelerates epithelization, facilitating wound healing, and provides astringent, firming, and reparative anti-stress benefits against diverse environmental aggressors.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Effective in wound healing, showing efficacy comparable to a positive control and promoting epithelization in animal studies.
- 02 Dry extract demonstrated an inhibitory action on phospholipase A2, lipoxygenase, and phosphodiesterase, indicating its usefulness in combating irritation, inflammation, and allergic reactions.
- 03 Methanolic and ethanolic extracts exhibited potent antioxidative and free-radical scavenging activity in the DPPH assay, with inhibitions ranging from 70.4% ± 4.9% to 77.8%.
Transparency
Dusting Analysis
There is no evidence to suggest that Terminalia Catappa Leaf Extract is commonly used at ineffective 'dusting' percentages in formulations.
The Formula
Formulation
Safety
Safety Profile
The oral LD50 in rats, estimated between ≤ 2000 - 5000 mg/kg, indicates a generally reasonable safety profile. However, it exhibited a tocolytic effect in pregnant rats, necessitating caution during human pregnancy, especially in the third trimester or during labor. No specific safety assessments by CIR or SCCS are available for this extract, although CosIng lists it as a skin conditioning agent. Rigorous product safety assessments are legally required for cosmetic products containing this ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Terminalia Catappa Leaf Extract is a valuable multi-active ingredient that offers significant antioxidant, anti-inflammatory, anti-aging, and protective benefits for a wide range of skin types, particularly dry, sensitive, and normal skin.
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References
Sources