Science
Mechanism of Action
This extract operates as a neurocosmetic by influencing the intricate connection between the skin and the brain, thereby promoting skin homeostasis. Its primary mechanism involves a significant reduction in the localized release of cortisol, a key stress hormone, by up to 70%. Concurrently, it stimulates the production of beneficial neurochemicals like β-endorphins (increasing by 163%) and dopamine, fostering a sense of comfort and well-being. At a cellular level, it up-regulates genes critical for antioxidant response and skin renewal, specifically inducing HMOX-1 and NQO-1 expression. Furthermore, it exhibits potent anti-inflammatory and antimicrobial properties, actively breaking down the biochemical cycle of stress in the skin, which helps prevent premature aging and improves the skin's overall conditioning, rendering it softer, smoother, and more supple.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Promoted the expression of main marker proteins involved in cellular and oxidative stress response in keratinocytes and fibroblasts, leading to improvement of the epidermal matrix, reduction of inflammation and redness, and stimulation of superoxide scavenger activity for antioxidant and pollution protection.
- 02 Reduced cortisol, the stress hormone, by up to 70% within two hours of topical application. Stimulated the release of β-endorphins by 163% within 24 hours (in vitro). Clinically demonstrated significant improvement in skin by reducing dark circles and diminishing skin redness at both 14 and 28 days in women aged 40-67 living in polluted environments.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract is water-soluble and can be obtained in preservative-free forms, such as Neurophroline™, which is often enhanced with specific sugars like stachyose and chicory inulin to maintain stability and efficacy.
Safety
Safety Profile
Generally considered safe for topical cosmetic application, with side effects being uncommon. However, a patch test is recommended to rule out rare occurrences of skin irritation or allergic reactions such as redness or itching. Data regarding topical use during pregnancy and breastfeeding is currently insufficient, therefore consultation with a healthcare professional is advised.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable neurocosmetic ingredient that effectively mitigates the visible impacts of stress on skin, offering comprehensive antioxidant, anti-inflammatory, and conditioning benefits suitable for all skin types.
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