Science
Mechanism of Action
This advanced extract functions multifacetedly within the skin's biological systems. It precisely targets and inhibits the synthesis of matrix metalloproteinase 1 (MMP-1), an enzyme implicated in collagen degradation, thereby effectively mitigating the structural breakdown associated with skin aging and wrinkle formation, with observed effects comparable to retinoic acid. Concurrently, its active compounds provide robust antioxidant defense by reducing reactive oxygen species and decreasing pro-inflammatory cytokines in keratinocytes. Furthermore, it safeguards human skin fibroblasts and blood vessel endothelial cells from damage induced by UV radiation and bacterial exposure. The extract also demonstrates inhibitory action against key enzymes, including superoxide-producing enzymes, lipoxygenase, tyrosinase, and 5-alpha-reductase, which are implicated in inflammatory responses, acne pathogenesis, and hyper-pigmentation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Significantly inhibits the synthesis of matrix metalloproteinase 1 (MMP-1), contributing to the reduction of collagen degradation, prevention of skin aging, and diminution of wrinkles. These anti-aging effects were found to be comparable to those of retinoic acid.
- 02 Meristem cell-derived active substances offer effective protection for human skin fibroblasts and blood vessel endothelial cells against damage caused by UV irradiation and bacterial exposure.
- 03 Reduces the production of deleterious cytokines and reactive oxygen species in human keratinocytes when exposed to pro-inflammatory cytokines or bacterial lipopolysaccharides.
- 04 Exhibits inhibitory action against various enzymes including superoxide-producing enzymes, lipoxygenase, tyrosinase, and 5-alpha-reductase, which are involved in inflammation, acne, hyper-pigmentation, and hair loss.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While the raw Taxus plant genus contains toxic compounds (taxoids) primarily in its leaves and seeds, posing ingestion risks, this cosmetic-grade meristem cell culture extract is expected to be meticulously processed to eliminate or minimize such compounds, making it suitable for topical application. General dermal, oral, and inhalation toxicity for the broader ingredient category are listed as 'not determined'. It is not recommended for use as a fragrance or flavor ingredient. No specific safety assessments by CIR, SCCS, or FDA were found for this particular extract.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This extract offers significant anti-aging, antioxidant, and anti-inflammatory benefits, demonstrating protective effects against environmental damage and addressing concerns like acne and hyper-pigmentation, making it a valuable addition for diverse skin types.
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References
Sources