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Moumoujus

TAIWANOFUNGUS CAMPHORATUS FERMENT EXTRACT.

Valuable / SKIN CONDITIONING

Taiwanofungus Camphoratus Ferment Extract, also known as Antrodia cinnamomea, is a potent botanical ferment prized for its multifaceted skin benefits. It acts as a powerful antioxidant and anti-inflammatory agent, while also offering significant skin conditioning and humectant properties. This extract holds promise for soothing compromised skin and improving overall skin health.

Summary

Cleansing Humectant Skin Conditioning Emollient Antioxidant Anti-inflammatory

Science

Mechanism of Action

This extract operates through multiple pathways to enhance skin vitality. As a robust antioxidant, it actively neutralizes reactive oxygen species (ROS), bolsters cellular defense by upregulating enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and helps restore NADPH levels, collectively protecting cells from oxidative damage. Its substantial anti-inflammatory capacity stems from inhibiting IL-17A-induced inflammation, modulating key inflammatory pathways such as NF-κB and mTOR, and reducing pro-inflammatory mediators like COX-2 protein expression, prostaglandin E2 (PGE2), IL-6, IL-4, IL-5, and TNF-α. Additionally, it contributes to skin conditioning by acting as a humectant and emollient, which helps to soften and smooth the skin's texture and supports the retention of vital components like hydroxyproline and hyaluronic acid. These actions collectively contribute to its anti-psoriatic and potentially anti-photodamaging effects.

Research

Clinical Evidence

Medium confidence
Effective range 10–205.7%
Optimal

N/A

Key findings

  1. 01 In *in vitro* studies, fermented Taiwanofungus camphoratus mycelia extract demonstrated significant antioxidant activity, with an EC50 value of 205.7 µg/mL for DPPH scavenging.
  2. 02 The extract maintained HaCaT cell viability above 80% at concentrations between 10-75 µg/mL, indicating low cytotoxicity, and within this range, ameliorated psoriasis-associated responses in these cells.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract's precise composition and subsequent stability can vary significantly depending on the specific fermentation and extraction methods employed (e.g., solid-state or submerged fermentation, choice of solvents). Specific optimal pH ranges for stability in cosmetic formulations have not been identified in the available data.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific safety assessments for topical application by regulatory bodies like CIR or SCCS were identified. It is listed as a cosmetic ingredient by COSMILE Europe, which underscores the legal requirement for comprehensive product safety evaluations for cosmetic formulations. An oral phase I clinical trial of an Antrodia cinnamomea extract (LEAC-102) administered to healthy adults at doses up to 2988 mg/day for one month reported no serious adverse effects, suggesting a general safety profile, although this pertains to oral intake rather than topical.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Taiwanofungus Camphoratus Ferment Extract is a valuable ingredient, demonstrating potent antioxidant, anti-inflammatory, and skin conditioning benefits with a low irritancy profile, making it suitable for a wide range of skin types and concerns.

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