Science
Mechanism of Action
This extract exhibits significant antioxidant activity by inhibiting IL-17A-induced intracellular oxidative stress and directly neutralizing free radicals. It also demonstrates anti-inflammatory effects by regulating IL-17A-induced inflammation and cell proliferation, primarily through the mTOR/p70S6K and NF-κB signaling pathways. Additionally, it possesses immunomodulatory properties, enhancing the activity of immune cells such as macrophages and natural killer cells.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In HaCaT cells, a fermented extract at 0.02057% demonstrated remarkable antioxidant ability, achieving an EC50 value in DPPH scavenging assays.
- 02 At a concentration of 0.05%, the extract showed antioxidant efficacy comparable to a positive control in DPPH scavenging assays in HaCaT cells.
- 03 It regulated IL-17A-induced inflammation and cell proliferation in HaCaT cells through the mTOR/p70S6K and NF-κB signaling pathways, indicating potential to ameliorate psoriasis-associated responses.
Transparency
Dusting Analysis
No data available to suggest this ingredient is commonly 'dusted' or used at ineffective concentrations in formulations.
The Formula
Formulation
Stability
Water-soluble metabolites have been identified, and extracts can be obtained using various solvents including water, methanol, ethanol, ethyl acetate, chloroform, and ether, suggesting a broad range of soluble components and robust formulation flexibility.
Safety
Safety Profile
No specific safety assessments by CIR or SCCS for cosmetic use were found. No specific FDA status for cosmetic use was identified. Oral administration of solid-state cultivated powder in mice, at doses up to 988 mg/kg bw, showed no toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Taiwanofungus Camphoratus Extract presents valuable in vitro antioxidant and anti-inflammatory capabilities, making it a promising ingredient for formulations aimed at protecting and calming various skin types.
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References
Sources