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Moumoujus

TABEBUIA IMPETIGINOSA LEAF EXTRACT.

Valuable CAS 223748-85-4 / SKIN CONDITIONING

Tabebuia Impetiginosa Leaf Extract is a botanical ingredient derived from the Pau D'Arco tree, valued for its anti-inflammatory, immunomodulatory, and antioxidant properties. Research indicates its potential to soothe skin and protect against cellular stress.

Summary

Anti-inflammatory Antioxidant Immunomodulatory Skin Conditioning

Science

Mechanism of Action

This extract exerts its primary effects by inhibiting key inflammatory pathways. It significantly suppresses the production of pro-inflammatory mediators, specifically nitric oxide (NO) and prostaglandin E2 (PGE2), and reduces the mRNA expression levels of COX-2 and iNOS in stimulated macrophages. Furthermore, it demonstrates immunomodulatory capabilities by influencing macrophage activity, including maintaining cellular cluster formation, downregulating phagocytic uptake, and enhancing cell-cell interactions. Its rich content of phenols contributes to its antioxidant capacity, offering protection against oxidative stress.

Research

Clinical Evidence

Medium confidence
Effective range 12.5–400%
Optimal

N/A

Key findings

  1. 01 An ethanol extract exhibited anti-inflammatory activity by inhibiting nitric oxide (NO) and prostaglandin E2 (PGE2) production, and suppressing COX-2 and iNOS mRNA levels in LPS-stimulated macrophages.
  2. 02 A water extract demonstrated immunomodulatory effects on RAW264.7 (murine macrophage) and U937 (human promonocytic) cells, characterized by maintained cluster formation, downregulated phagocytic uptake, and upregulated cell-cell interactions.
  3. 03 Isolated cyclopentene derivatives from the extract effectively suppressed NO and PGE2 production in RAW264.7 cells.
  4. 04 A methanolic extract showed cytotoxic effects on various human tumor cell lines (GI50 76.67-110.76 µg/mL) but exhibited no toxicity to non-tumor porcine liver primary cells up to >400 µg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

There is no specific safety review by the Cosmetic Ingredient Review (CIR) or SCCS for Tabebuia Impetiginosa Leaf Extract. Data from sources like EWG and INCI Beauty indicate 'No Data' for skin allergies and irritation, and 'No penalty' across categories, suggesting a lack of reported adverse reactions.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Tabebuia Impetiginosa Leaf Extract is a valuable botanical ingredient demonstrating promising in vitro anti-inflammatory, immunomodulatory, and antioxidant capabilities, indicating significant potential for skin health, though further human clinical data is needed to confirm topical efficacy.

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