Science
Mechanism of Action
This extract functions as a humectant and skin conditioning agent, effectively maintaining epidermal water content. Its anti-inflammatory properties, attributed to phytochemicals like flavonoids and tannins, mitigate local inflammation associated with various skin conditions. As a robust antioxidant, it neutralizes reactive oxygen species, thereby shielding skin cells from oxidative stress and environmental damage. The extract also demonstrates antimicrobial activity by inhibiting bacterial growth, including *Cutibacterium acnes*, through mechanisms such as cell wall disruption, enzyme inhibition, interference with quorum sensing, and generation of reactive oxygen species. Additionally, its astringent nature contributes to skin tightening and a refined pore appearance, while research indicates potential for enhanced collagen synthesis and support for wound healing.
Research
Clinical Evidence
High confidence15%
Key findings
- 01 At 700µg/mL, it exhibited 78.59% radical scavenging activity, demonstrating potent antioxidant protection with very low irritation potential and low cytotoxicity.
- 02 Ethanolic extract at 2500 µg/ml showed significant antibacterial activity, yielding a 15 mm zone of inhibition against *Streptococcus mutans* and 12 mm against *Staphylococcus aureus*.
- 03 Aqueous extract achieved optimal antimicrobial efficacy at a 15% concentration.
- 04 Demonstrated strong DPPH and ABTS radical scavenging activity with EC50 values of 88.67 ± 3.05 µg/mL and 91.78 ± 5.27 µg/mL respectively.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal pH of 3.5 has been reported for the antimicrobial efficacy of an aqueous extract. A traditional powdered formulation exhibited a pH of 4.29, suggesting its suitability and stability within an acidic environment.
Safety
Safety Profile
No formal CIR or SCCS safety assessment is available. However, acute toxicity studies in rats indicated no signs of toxicity or mortality at doses up to 2000 mg/kg. It has demonstrated very low irritation potential and low cytotoxicity in *in vitro* models at 700µg/mL. Historically, this ingredient has been utilized safely for centuries in Ayurvedic and Unani medicine. Specific dermal toxicity data is yet to be determined.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Symplocos Racemosa Bark Extract is a valuable botanical ingredient offering a broad spectrum of benefits, including significant antioxidant, anti-inflammatory, and antimicrobial actions, making it suitable for diverse precision skincare formulations.
Related
Similar Ingredients
Finding similar ingredients…