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Moumoujus

SYMPHYTUM OFFICINALE LEAF EXTRACT.

Avoid CAS 84696-05-9 / SKIN CONDITIONING

Symphytum officinale leaf extract, commonly known as comfrey, is valued for its multi-functional properties that support skin regeneration, soothing, and anti-aging. It enhances cellular renewal, provides antioxidant and anti-inflammatory benefits, and offers both hydration and astringent effects.

Summary

soothing anti-inflammatory wound healing cell regeneration antioxidant collagen formation support astringent humectant keratinolytic anti-fungal anti-viral anti-bacterial

Science

Mechanism of Action

The extract's efficacy is attributed to a rich composition of bioactive compounds. Allantoin, a key constituent, stimulates cellular regeneration and growth, aiding in the repair of damaged tissues, accelerating wound healing, and minimizing scars. Allantoin additionally supports collagen formation, contributing to improved skin suppleness and a reduction in the appearance of fine lines and wrinkles. Rosmarinic acid and other phenolic acids provide potent anti-inflammatory and antioxidant activities, mitigating redness, swelling, and irritation while protecting the skin from free radical damage and environmental aggressors. Tannins impart astringent properties, which help to firm the skin, refine pore appearance, regulate sebum production, and offer antimicrobial protection. Furthermore, its mucilage content functions as a humectant, drawing and retaining moisture to deeply hydrate the skin, alleviate dryness and flakiness, and form a protective barrier. Chlorogenic acid further contributes anti-fungal, anti-viral, and anti-bacterial benefits.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A study in the 'Journal of Cosmetic Dermatology' reported that comfrey extract enhanced skin elasticity and visibly reduced fine lines and wrinkles.
  2. 02 Research published in the 'Journal of Wound Care' indicated that comfrey extract significantly accelerated the wound healing process.
  3. 03 Studies highlight the extract's richness in rosmarinic acid, demonstrating notable antioxidant and anti-inflammatory activities.

Transparency

Dusting Analysis

Not commonly dusted

There is no evidence to suggest this ingredient is commonly 'dusted' at sub-effective concentrations; rather, concerns exist regarding potential health risks at higher concentrations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Symphytum officinale leaf extract is controversial due to the presence of pyrrolizidine alkaloids (PAs), which are associated with potential hepatotoxicity, primarily upon oral ingestion, but concerns extend to topical applications at high concentrations. Leaf extracts typically contain lower PA levels (15-55 µg/g) compared to root extracts (1380-8320 µg/g). It is strongly recommended to use only certified PA-free extracts and perform patch testing prior to widespread application. The EWG classifies this ingredient as 'Restricted' due to potential toxic impurities. In Germany, a permissible dermal dose of PAs is 100 µg/day, with treatment duration limited to 4-6 weeks per year if the dose ranges between 10-100 µg/day. This ingredient should not be applied to new or deep cuts.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

While Symphytum officinale leaf extract presents promising regenerative and soothing benefits, its inherent safety concerns related to pyrrolizidine alkaloids (PAs) dictate an 'avoid' rating for precision skincare, unless a certified PA-free extract is rigorously sourced and tested.

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