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Moumoujus

SYMPHYTUM OFFICINALE CALLUS CULTURE LYSATE.

Valuable / SKIN CONDITIONING

Derived from comfrey plant stem cells, Symphytum Officinale Callus Culture Lysate is engineered to revitalize aging skin. It works by stimulating natural epidermal renewal processes, leading to noticeable improvements in skin texture and hydration.

Summary

Antioxidant Anti-Aging Skin Conditioning Epidermal Renewal Hyaluronic Acid Synthesis Skin Smoothing Soothing

Science

Mechanism of Action

This advanced lysate stimulates the proliferation of epidermal stem cells, thereby rejuvenating the skin's inherent renewal potential and accelerating the epidermal turnover rate. Studies indicate it significantly enhances the synthesis of hyaluronic acid within 3D epidermis models and increases epidermal thickness by up to 88% under pro-aging conditions. Rich in phenolic compounds such as rosmarinic and caffeic acids, it also provides antioxidant and calming benefits, actively combating visible signs of aging and supporting overall skin health.

Research

Clinical Evidence

Medium confidence
Effective range 0.4–1%
Optimal

N/A

Key findings

  1. 01 A vehicle-controlled clinical study demonstrated that concentrations between 0.4-1% significantly improved epidermal turnover rate and skin smoothness after four weeks of application.
  2. 02 An in-vivo study involving 20 women (aged 40-60) reported an 8% reduction in skin renewal time and approximately a 12% improvement in skin smoothness over 56 days when applied twice daily within a cream formulation.
  3. 03 In-vitro studies using 3D epidermis models confirmed an enhanced synthesis of hyaluronic acid.
  4. 04 Further in-vitro research revealed an 88% increase in epidermal thickness under simulated pro-aging conditions.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

As of the latest review (2022-2023), the independent Cosmetic Ingredient Review (CIR) panel has not yet evaluated Symphytum officinale callus culture extract. It is noteworthy that while traditional comfrey extracts may contain pyrrolizidine alkaloids associated with irritation, the callus culture lysate is specifically formulated to mitigate these concerns, contributing to its low irritancy profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

With robust evidence for enhancing skin renewal, smoothness, and hydration, alongside antioxidant and soothing properties, this ingredient is a valuable asset for advanced anti-aging and skin vitality formulations.

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