SYMPHORICARPOS ALBUS FRUIT EXTRACT.

This precision extract, particularly in its fermented form, exerts its benefits by modulating crucial gene expression within skin cells. It stimulates AQP-3 (aquaporin 3) gene expression by approximately 1.47-fold in keratinocytes, optimizing water transport and epidermal hydration. Concurrently, it increases HAS-3 gene expression by approximately 1.45-fold, contributing to the endogenous synthesis of hyaluronic acid for improved skin elasticity and moisture retention. Furthermore, it promotes COL1A1 (collagen type I alpha 1) gene expression by nearly 1.89-fold in dermal fibroblasts, which is essential for maintaining robust skin structure and mitigating wrinkle formation. The extract's rich phenolic content, including ferulic acid, is theorized to be instrumental in these beneficial gene activations. Beyond gene modulation, it acts as an antioxidant, neutralizing reactive oxygen species and providing cellular protection against environmental stressors. It also inhibits MMP-1, a matrix metalloproteinase responsible for collagen degradation, thus safeguarding skin integrity. Ancillary benefits may include the activation of PPARγ for enhanced skin barrier function, as well as anti-inflammatory and brightening properties.