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SULFATED SODIUM CHONDROITIN SULFATE.

Valuable / SKIN CONDITIONING

Sulfated Sodium Chondroitin Sulfate is a glycosaminoglycan (GAG), related to hyaluronic acid, that functions as a potent humectant to enhance skin hydration and maintain elasticity. It supports the skin's natural moisture barrier by forming a water-rich film and mimicking natural moisturizing factors (NMFs).

Summary

Humectant Skin conditioning Anti-inflammatory Protective film-forming

Science

Mechanism of Action

As a glycosaminoglycan, Sulfated Sodium Chondroitin Sulfate effectively binds water, forming a protective, moisture-rich film on the skin's surface. This action significantly reduces transepidermal water loss, contributing to smoother, softer, and more supple skin. It mimics the skin's natural moisturizing factors, helping to replenish aged mucopolysaccharides and support their regeneration, thereby maintaining skin's bounce and reducing inflammation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

5%

Key findings

  1. 01 In vitro studies on human keratinocyte (HaCaT) cells demonstrated no cytotoxicity at concentrations between 0.016 mg/mL and 0.08 mg/mL.
  2. 02 An ex vivo study using a solid lipid nanoparticle (SLN) formulation optimized for skin permeation included Chondroitin Sulfate Sodium at 5-11% in its aqueous matrix to enhance penetration through pig ear skin.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 7.5
0 7 14

Stability

A solution of Sodium Chondroitin Sulfate is stable within a pH range of 5.5 to 7.5.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Chondroitin sulfate sodium is 'Generally Recognized As Safe (GRAS)' by the FDA for oral consumption up to 1200 mg/person/day, and its injectable form is FDA-approved for ophthalmic use. Topically, it exhibits an excellent safety profile with no reported side effects and is considered gentle. However, individuals with fish protein allergies should be aware of a potential risk if the ingredient is marine-derived, and a patch test is recommended for those prone to sensitivity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A valuable skin-identical humectant known for its hydrating, film-forming, and soothing properties, Sulfated Sodium Chondroitin Sulfate is highly compatible with all skin types and presents a low risk of irritation.

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