Science
Mechanism of Action
This extract demonstrates potent anti-oxidative effects by scavenging free radicals, as assessed through radical generation assay systems like the xanthine oxidase assay, and electron-donating activity systems, such as the DPPH assay. Its anti-inflammatory properties stem from suppressing nitric oxide (NO) production and inhibiting the expression of inducible NO synthase (iNOS) in stimulated cells; additionally, specific fractions modulate the mRNA expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) and monocyte chemoattractant protein 1 (MCP-1).
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated potent anti-oxidative effects with IC50 values ranging from 9 to 42 microg/ml, assessed via radical generation (xanthine oxidase assay) and electron-donating (DPPH assay) systems.
- 02 At 0.1 microg/ml in LPS-induced RAW264.7 cells, the extract significantly suppressed nitric oxide (NO) production. The chloroform fraction completely blocked inducible NO synthase (iNOS) expression, while hexane and chloroform fractions suppressed mRNA expression of GM-CSF and MCP-1.
Transparency
Dusting Analysis
No specific data regarding dusting analysis for Suaeda Asparagoides Extract is available in the provided research.
The Formula
Formulation
Stability
A cream containing 0.3% Suaeda Asparagoides ethyl acetate extract exhibited a slight pH decrease of 0.08 units when stored at 4-25°C, a more pronounced decrease of 0.51 units at 45°C, and 0.66 units under sunlight over a 12-week period. The extract contributed to the emulsion's stability by protecting against viscosity reduction upon sun exposure, with no observed changes in color or smell. Further long-term stability studies in diverse cream formulations are required for comprehensive assessment.
Safety
Safety Profile
There is currently no official safety assessment or available information from major regulatory bodies such as the Cosmetic Ingredient Review (CIR), the Scientific Committee on Consumer Safety (SCCS), or the FDA concerning Suaeda Asparagoides Extract for cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While demonstrating promising in-vitro antioxidant and anti-inflammatory benefits across all skin types, the absence of comprehensive safety reviews by regulatory bodies necessitates further research before recommending its widespread use in precision skincare.
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References
Sources