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Moumoujus

STURGEON POLYPEPTIDE-1.

Valuable / NOT REPORTED

Sturgeon Polypeptide-1 is a sophisticated bio-active peptide derived from sturgeon, distinguished by its potent anti-inflammatory, antioxidant, and reparative capabilities. It actively works to soothe irritated skin, protect against environmental oxidative stress, and bolster the skin's intrinsic regeneration processes.

Summary

Anti-inflammatory Antioxidant Skin Repair Collagen Support Reduces Photodamage Soothes Skin

Science

Mechanism of Action

This peptide operates at a cellular level by modulating key inflammatory pathways, such as MAPK and NF-κB, leading to a significant reduction in pro-inflammatory mediators including nitric oxide (NO), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Furthermore, it acts as a powerful antioxidant, effectively neutralizing reactive oxygen species (ROS) and alleviating oxidative damage. Beyond protective actions, Sturgeon Polypeptide-1 actively supports skin rejuvenation by increasing collagen Iα1 synthesis and inhibiting matrix metalloproteinase (MMP) activity, thereby promoting skin repair and mitigating photodamage.

Research

Clinical Evidence

Medium confidence
Effective range 12.5–800%
Optimal

N/A

Key findings

  1. 01 Demonstrated anti-inflammatory effects by decreasing inflammatory mediators (NO, IL-6, IL-1β) and enhancing superoxide dismutase (SOD) activity in LPS-induced RAW264.7 macrophages at a concentration of 0.25 mg/mL.
  2. 02 Showed potential for repairing UVB-irradiated skin damage in a zebrafish model and reduced oxidative stress (ROS, malondialdehyde) while inhibiting pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, Cox-2) in mouse fibroblast L929 cells at concentrations between 0.125 and 0.25 mg/mL. This also included increased collagen Iα1 content and inhibited matrix metalloproteinase expression.
  3. 03 Exhibited anti-inflammatory activity by inhibiting nitric oxide and reducing IL-6 production, while increasing IL-10, through suppression of MAPK channels, with effective concentrations ranging from 12.5 to 800 µg/mL.

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that Sturgeon Polypeptide-1 is commonly 'dusted' in formulations, nor are specific dusting thresholds defined.

The Formula

Formulation

Solubility
Water
Optimal pH 1 – 11
0 7 14

Stability

This ingredient demonstrates remarkable stability across a wide pH spectrum, maintaining its zinc-binding capacity above 66% from pH 1 to 11. Optimal conditions for enzymatic hydrolysis to produce sturgeon skin collagen hydrolysates are noted at pH 7 or 8, within temperatures of 35.5°C to 50°C.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not yet reviewed Sturgeon Polypeptide-1. While direct safety data for this specific polypeptide is limited, a related ingredient, Sr-(Methionyl Sturgeon Polypeptide-1), has been noted for a potential, albeit low, likelihood of irritation, which may increase when combined with other sensitizing ingredients. Specific studies on pregnant or lactating individuals are unavailable.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sturgeon Polypeptide-1 is a valuable ingredient with demonstrated anti-inflammatory, antioxidant, and skin-reparative properties in in vitro and animal models, though further human clinical data would strengthen its profile.

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