Science
Mechanism of Action
This extract operates through several key pathways: its high concentration of tannins and polyphenolic compounds confers significant astringent properties, leading to visible tissue constriction, a reduction in pore size, enhanced skin firmness, and effective regulation of sebum production. As an antioxidant, it actively neutralizes free radicals and inhibits lipid peroxidation, protecting cellular integrity. It modulates inflammatory responses by decreasing the expression of pro-inflammatory cytokines and promoting vasoconstriction. Furthermore, its antimicrobial action, particularly against Staphylococcus aureus, is attributed to phenols disrupting bacterial cell walls. In wound healing contexts, it stimulates keratinocyte proliferation, collagen synthesis, extracellular matrix organization, and the formation of new blood vessels (angiogenesis). The extract also targets specific skin concerns, including hyperpigmentation, folliculitis, and acne.
Research
Clinical Evidence
Medium confidence6%
Key findings
- 01 In a double-blind, randomized, placebo-controlled human trial, a cream containing this extract was effective in reducing and reversing excess terminal hair, skin hyperpigmentation, folliculitis, and acne.
- 02 An ointment formulated with 10% aqueous bark extract demonstrated complete epithelization in rat cutaneous wounds after 14 days, alongside superior recovery from inflammation and enhanced neovascularization.
- 03 An aqueous extract at 3% showed potential to promote angiogenesis, indicating its role in stimulating new blood vessel formation essential for tissue repair.
- 04 In vitro studies revealed anti-inflammatory effects through a decrease in the protein and gene expression of pro-inflammatory cytokines.
- 05 Minimum inhibitory concentrations (MICs) against various Staphylococcus aureus strains were established, with 125 µg/mL effectively inhibiting S. aureus ATCC 25923 and 250 µg/mL for most other strains, highlighting its antimicrobial potential.
Transparency
Dusting Analysis
Stryphnodendron Adstringens Bark Extract is not considered a 'dusting' ingredient due to a robust body of research, including a double-blind, randomized, placebo-controlled human trial demonstrating efficacy at 6.0% for several significant skin concerns, alongside numerous in vitro and animal studies supporting its multifaceted benefits.
The Formula
Formulation
Stability
Aqueous extracts are frequently utilized, demonstrating good stability. For formulations requiring higher tannin content, 80% propylene glycol can serve as an effective solvent. Water remains a preferred solvent for industrial-scale applications due to its environmental benefits.
Safety
Safety Profile
No specific CIR, SCCS, or FDA regulatory status has been established. While human safety studies are limited, in vitro tests indicate cell viability remains above 70% at safe concentrations. High oral doses in animal studies have shown toxic effects on various systems (CNS, respiratory, gastrointestinal), and are linked to decreased body weight, thymic involution, and increased plasma glucose. Given the existing data, topical application is generally considered low irritancy, but oral ingestion is not recommended for pregnant or lactating individuals.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Stryphnodendron Adstringens Bark Extract is a valuable, multi-beneficial ingredient for Moumoujus, offering proven efficacy in addressing a range of skin concerns from acne and hyperpigmentation to wound healing, supported by human clinical data at an optimal 6.0% concentration.
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References
Sources