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Moumoujus

STRONTIUM CHLORIDE HEXAHYDRATE.

Valuable CAS 10025-70-4 / ORAL CARE, SKIN CONDITIONING

Strontium Chloride Hexahydrate is a precise active ingredient recognized for its rapid and significant ability to soothe inflamed, irritated, and itchy skin. It works to alleviate discomfort, reduce redness, and improve skin hydration, making it particularly beneficial for sensitive skin types. Its multi-faceted mechanism targets key inflammatory and itching pathways for effective relief.

Summary

Anti-inflammatory Anti-itch Soothing Redness Reduction Skin Hydration Support Calming

Science

Mechanism of Action

This ingredient systematically suppresses inflammation by blocking TNF-alpha and preventing the release of Substance P. It also interferes with calcium uptake in cells and exerts an anti-itch effect associated with histamine modulation. Strontium can substitute calcium to influence type C nerve activity and modify the permeability of other ion channels, thereby elevating the perception threshold for itching. Preliminary research in a C. elegans model also suggests potential anti-aging benefits by influencing developmental processes and lifespan.

Research

Clinical Evidence

High confidence
Effective range 1–6%
Optimal

N/A

Key findings

  1. 01 In clinical trials on sensitive skin, these concentrations significantly improved skin hydration and reduced erythema caused by irritants, showing a beneficial effect without a clear dose-response relationship across this range.
  2. 02 A topical hydrogel containing 4% Strontium Chloride Hexahydrate significantly reduced both the peak intensity and duration of non-histaminergic (cowhage-induced) and histamine-mediated itch. This effect was superior to hydrocortisone and diphenhydramine.
  3. 03 Provided rapid relief (within two minutes) for severe burning-prickling sensations and irritation post-shaving, with redness disappearing within 20 minutes. It also relieved burning from first-degree hot water burns within one minute, reducing redness in an hour, and instantly eased burning-prickling sensations associated with longer-term inflammation (intertrigo).
  4. 04 Animal studies demonstrated lower immunohistochemical TNF-alpha levels and reduced histopathological wound scores, indicating effective suppression of inflammation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7.5
0 7 14

Stability

The material is stable under normal ambient storage and handling conditions. Decomposition may occur at temperatures above 60 °C. For optimal stability, store in a dry place, protected from direct sunlight, air contact, and moisture.

Conflicts

  • strong acids
  • strong bases
  • oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Safety Data Sheets indicate serious eye damage, Strontium Chloride Hexahydrate is not classified as corrosive or irritant to the skin. It is also not considered a respiratory or skin sensitizer, germ cell mutagenic, carcinogenic, or a reproductive toxicant. Although no specific maximum concentration for cosmetic use is established by regulatory bodies, topical clinical studies have safely utilized concentrations up to 6%.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Strontium Chloride Hexahydrate is a valuable active for precision skincare, offering rapid relief from irritation, burning, and itching, particularly beneficial for sensitive and inflamed skin conditions due to its robust anti-inflammatory and soothing properties.

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