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Moumoujus

STRONTIUM CHLORIDE.

Valuable CAS 10476-85-4 / ORAL CARE, SKIN CONDITIONING, SOOTHING

Strontium Chloride is a precision mineral salt employed in advanced skincare for its potent ability to mitigate skin discomfort. It precisely targets and alleviates sensations of burning, prickling, and non-histaminergic itch, offering significant relief for reactive and irritated skin conditions.

Summary

Skin conditioning Soothing Anti-itch Anti-irritation

Science

Mechanism of Action

This ingredient exerts its calming effects by systematically interfering with key inflammatory pathways. It specifically blocks TNF alpha and curtails the release of Substance P, both prominent mediators of pain and irritation in the skin. Furthermore, strontium ions modulate cellular activity by outcompeting calcium for ion channels and altering local calcium availability, thereby reducing cellular responsiveness linked to itching and neurotransmitter release.

Research

Clinical Evidence

High confidence
Effective range 4–6%
Optimal

N/A

Key findings

  1. 01 Demonstrated efficacy in relieving severe burning-prickling sensations and serious irritation, including discomfort post-shaving, first-degree burns, and sensations associated with intertrigo.
  2. 02 A topical hydrogel formulation containing 4% Strontium Chloride significantly reduced the peak intensity and duration of cowhage-induced itch, highlighting a robust antipruritic effect against non-histaminergic pruritus.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
3.8%
Red flag below
4%

While the Scientific Committee on Consumer Safety (SCCS) approves Strontium Chloride use in cosmetics up to 3.8% (as SrCl2), clinical studies showcase significant efficacy at concentrations of 4% and even 6%. This discrepancy presents a risk that formulations aiming for optimal therapeutic benefits might exceed the recommended maximum, potentially leading to concentrations considered 'dusted' above established safety guidelines.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Strontium Chloride forms neutral to slightly alkaline aqueous solutions (pH 5.0-7.0 at 50 g/L). It maintains stability under normal ambient conditions but requires storage in a cool, dry place, away from direct sunlight, high temperatures, and moisture to ensure integrity.

Conflicts

  • strong acids
  • strong bases
  • oxidizing agents
  • 2-Furan percarboxylic acid
  • moisture

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
3.8%
Sensitization risk Low

The Scientific Committee on Consumer Safety (SCCS) has approved Strontium Chloride hexahydrate for cosmetic applications, stipulating a maximum in-use concentration of 3.8% (calculated as SrCl2). Their assessment indicated a low risk for acute oral and dermal toxicity, favorable irritation and corrosivity profiles, and no reported sensitization. However, it is essential to acknowledge that in its raw or highly concentrated form, general Safety Data Sheets classify Strontium Chloride with hazard statements including potential skin irritation and serious eye damage.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Strontium Chloride is a valuable ingredient for precision skincare, offering scientifically backed relief for sensitive, irritated, and itchy skin, provided formulations adhere to established safety concentration guidelines.

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