Science
Mechanism of Action
This ingredient actively conditions the skin, aiming to restore and maintain its optimal state. Key actions stem from components like Spirodela polyrhiza, recognized for its moisturizing apiogalacturonans, alongside demonstrable antioxidant and anti-inflammatory properties. Spirodela polyrhiza extract has been shown to precisely modulate ion channels implicated in atopic dermatitis, specifically inhibiting Orai1 activity by 63.8% and elevating TRPV3 activity by 81.29% at -100 mV in HEK293T cells, while also suppressing mast cell degranulation. Lithospermum officinale, with historical use in managing various skin conditions, further contributes to its anti-inflammatory potential. The inclusion of 'Ferment Filtrate' signifies that fermentation by Streptomyces subrutilus has likely optimized the bioavailability and overall efficacy of the complex's bioactive compounds.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
Insufficient data available to determine if this complex ingredient is commonly dusted or to establish a dusting threshold.
The Formula
Formulation
Stability
Specific stability data for the complete complex are not detailed in the available research.
Synergies
- The combination of botanical extracts within this complex, particularly including Lithospermum erythrorhizon and Spirodela polyrhiza, has demonstrated synergistic effects, exhibiting superior anti-atopic dermatitis outcomes compared to individual components. The fermentation process with Streptomyces subrutilus is also expected to enhance ingredient efficacy and bioavailability.
Safety
Safety Profile
The comprehensive complex has not undergone specific safety assessments by bodies such as CIR, SCCS, or FDA. However, individual component data, particularly for Spirodela polyrhiza extract, indicates a favorable safety profile, with non-independent tests showing it to be non-cytotoxic, non-irritating, non-sensitizing, non-mutagenic, and non-phototoxic in topical applications. Further formal review for the complete ingredient would provide additional certainty.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This fermented botanical complex presents a valuable profile for skin health, offering robust anti-inflammatory, moisturizing, and barrier-supporting properties, making it particularly well-suited for sensitive, dry, and atopic skin concerns.
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References
Sources