Science
Mechanism of Action
The ferment filtrate operates through a synergistic blend of postbiotic compounds and botanical actives. *Streptococcus Thermophilus* ferment filtrate is observed to strengthen the skin's protective barrier by stimulating the production of essential lipids, particularly ceramides, thereby supporting hydration and defense against environmental stressors. It also promotes skin renewal and exhibits anti-inflammatory effects beneficial for sensitive and dry skin, alongside anti-fibrotic potential through specific cellular pathway modulation. *Lactobacillus* ferment contributes DNA repair enzymes, offers protection against environmental aggressors, and provides antimicrobial and anti-inflammatory benefits by balancing the skin's microflora, which is particularly effective against acne and rosacea. Licorice Root Extract, primarily through its glabridin and glycyrrhizin components, delivers significant depigmenting effects by inhibiting tyrosinase, coupled with potent anti-inflammatory and antioxidant properties. Collectively, these components restore acidic skin pH, alleviate oxidative stress, and significantly improve overall skin barrier function.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Topical application of *Streptococcus thermophilus* for 7 days significantly increased ceramide production in patients with acne.
- 02 *Lactobacillus* ferment at 5% concentration demonstrated effective anti-acne properties, leading to a faster reduction in the size and redness of acne lesions compared to salicylic acid.
- 03 *Lactobacillus* ferment at 1% concentration was shown to reduce skin sensitivity.
- 04 Topical application of glabridin (an active component from licorice root extract) at 0.5% concentration inhibited UVB-induced pigmentation in guinea pigs.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While an optimal pH range for the combined ferment filtrate's stability in cosmetic formulations is not directly specified, similar bacterial cultures (e.g., *Streptococcus thermophilus*) have shown viability in pH ranges such as 4.4-4.7 after incubation, with optimal culture enumeration at a regulated medium pH of 6.8 ± 0.1. As a filtrate, it is likely water-soluble.
Conflicts
- Formulators should be cautious regarding the depigmenting potential of ferment byproducts, particularly those derived from Lactobacillus, to ensure the cosmetic product does not exert drug-like skin lightening effects.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has deemed 'Lactobacillus Ferment Ingredients,' including Lactobacillus Ferment Filtrate, as safe for use in cosmetics. Lactobacillus Ferment has been reported at concentrations up to 5.6% in face and neck products. *Streptococcus Thermophilus* Ferment Filtrate generally exhibits an excellent safety profile with minimal reported serious side effects, though mild irritation or allergic reactions are possible in sensitive individuals. The FDA's approval of similar probiotic combinations pertains to *ingested* supplements, not topical cosmetic applications. Formulators are advised to carefully manage the tyrosinase-inhibiting properties to prevent unintended skin depigmentation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multi-component ferment filtrate is a valuable ingredient, offering significant benefits for skin barrier integrity, inflammation reduction, antimicrobial balance, and even-toned skin across all skin types, with a generally low risk of irritation.
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