Science
Mechanism of Action
This ingredient functions by modulating the skin's microbial ecosystem, competing with potentially harmful microbes and bolstering the skin's natural protective barriers. It may also produce enzymes, such as MdpS, which interact with host proteins like MUC5B, exhibiting mild immunomodulatory activity through IgA cleavage. Furthermore, Streptococcus oralis can downregulate pro-inflammatory responses and induce the production of defensins, like hBD-2, which aids in counteracting the colonization of pathogenic species on the skin.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The protease MdpS, produced by S. oralis, demonstrates activity within a pH range of 6.5 to 7.5. S. oralis is also described as acid-sensitive, generating alkaline metabolites to adapt its environment, suggesting optimal activity and growth conditions for related Streptococcus species around pH 7.0.
Safety
Safety Profile
Streptococcus oralis is a naturally occurring commensal bacterium common to the human oral cavity and other tracts. While generally considered benign, it can act as an opportunistic pathogen in specific circumstances, such as in immunocompromised individuals or in serious conditions like infective endocarditis. Despite being listed in the COSMILE Europe database as a skincare ingredient, no specific safety assessments from regulatory bodies like CIR, SCCS, or FDA for its cosmetic use have been identified.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Streptococcus oralis demonstrates a promising mechanism for skin microbiome balancing and immune modulation; however, specific clinical efficacy data for topical application and comprehensive cosmetic safety assessments are currently limited.
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References
Sources