Science
Mechanism of Action
This advanced extract operates by accelerating the skin's natural self-renewal cycle, enabling improved adaptation to external aggressors. It significantly boosts the synthesis of crucial proteins and enzymes vital for maintaining the structural integrity of the stratum corneum and enhances the production of antimicrobial peptides (AMPs). Functionally, it promotes epidermal growth and increases the stratum corneum's thickness. The extract specifically upregulates the gene expression of intercellular adhesion proteins like Occludin, Desmocollin 1, and Desmoglein 1, along with enzymes such as Kallikrein 5 and 7, which facilitate controlled shedding of dead skin cells. Furthermore, it exerts anti-inflammatory effects by inhibiting angiotensin-converting enzyme and absorbing UVB radiation, thereby safeguarding epidermal keratinocytes from damage and reducing interleukin-8 production. It actively supports a balanced skin microbiome and strengthens the overall skin barrier system. Certain strains within this extract also exhibit direct antibacterial action against common pathogens like Staphylococcus aureus and Escherichia coli, coupled with antioxidant properties.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 A water-soluble extract derived from heat-killed Lactococcus lactis H61 demonstrated a notable increase in normal human epidermal keratinocyte survival and suppressed interleukin-8 production in UVB-exposed cells, thereby alleviating photodamage and reducing inflammatory responses.
- 02 An emollient formulated with bacterial derivatives, specifically Lactococcus lactis lysate, exhibited excellent skin tolerability and compatibility, including for sensitive and atopic skin, leading to improved skin barrier function and a reduction in inflammatory markers.
- 03 Investigations using a reconstructed human epidermis model revealed that Lactococcus lactis upregulated 7.0% of genes directly relevant to skin health and function.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract is generally stable. While the optimal pH for the source bacteria's activity is 6.0-6.9, the extract's stability in a finished cosmetic formulation may accommodate a broader pH range.
Safety
Safety Profile
While a specific review by the Cosmetic Ingredient Review (CIR) Expert Panel for 'Streptococcus Lactis Extract' is pending, the foundational bacterium, Lactococcus lactis, holds a Generally Recognized As Safe (GRAS) designation from the FDA for its extensive history in food fermentation. Broader categories like 'Lactobacillus Ferment ingredients' have been concluded as safe for cosmetic applications by the CIR Expert Panel. It is important to note that the concentrated raw extract may exhibit irritant properties; however, this concern is mitigated in diluted cosmetic formulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Streptococcus Lactis Extract is a valuable ingredient for promoting skin renewal, fortifying the barrier, reducing inflammation, and maintaining overall skin health across all skin types.
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